Towards Superior Engineered T Cells

Source https://www.fightaging.org/archives/2024/05/towards-superior-engineered-t-cells/

Both cancer and aging impair the activity of T cells of the adaptive immune system, forcing these cells into exhaustion and senescence. The state of exhaustion is incompletely understood, but appears as an issue in immunotherapies making use of engineered T cells, as well as in the natural population of the aged body. Since researchers are already altering the T cells used in cancer therapies, why not alter them further to make them more able to resist the effects of aging cancer on T cell populations in the body? This is an interesting and plausible goal, but one that requires a greater understanding of T cell exhaustion than presently exists.

Cellular immu…

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