Towards a Small Molecule Therapy to Promote Remyelination

Source https://www.fightaging.org/archives/2024/05/towards-a-small-molecule-therapy-to-promote-remyelination/

Researchers here report on their efforts to interfere in a mechanism causing loss of the myelin that sheathes nerves. The driving goal is to produce a therapy for the severe demyelinating disease of multiple sclerosis rather than to reverse the lesser degree of myelin loss that occurs for everyone in later life. The animal evidence suggests that it may also prove to be useful in the general population of older individuals, however, which is promising. Loss of myelin is thought to contribute to some fraction of age-related loss of cognitive function, and so reversing that loss is an important goal.

Oligodendrocytes (OLs)<…