Many mechanisms are thought to contribute to the age-related decline of muscle mass and strength, but there are the usual debates over which are more important, which are the primary causes, and how they relate to one another. Little of our biochemistry is as fully understood as we might like it to be, and in some senses even the very well understood regions are only sketches of a yet to be fully mapped environment. One hypothesis places degeneration of neuromuscular junctions as an early cause, leading to the other observed issues. A neuromuscular junction is the synaptic connection between a motor neuron and muscle fiber, allowing the muscle to…
Loss of TRIO Expression at Neuromuscular Junctions Precedes Age-Related Loss of Motor Function
Many mechanisms are thought to contribute to the age-related decline of muscle mass and strength, but there are the usual debates over which are more important, which are the primary causes, and how they relate to one another. Little of our biochemistry is as fully understood as we might like it to be, and in some senses even the very well understood regions are only sketches of a yet to be fully mapped environment. One hypothesis places degeneration of neuromuscular junctions as an early cause, leading to the other observed issues. A neuromuscular junction is the synaptic connection between a motor neuron and muscle fiber, allowing the muscle to…