Reprogramming occurs in the early embryo, a conversion of adult germ cells into embryonic stem cells mediated by expression of the Yamanaka factors – canonically Oct3/4, Sox2, Klf4, and c-Myc. This is accompanied by a reset of age-related changes in gene expression, and a clearing out of cell damage and dysfunction. This process cannot fix everything, but in conjunction with the ability to selectively sacrifice embryonic cells with too great a burden of molecular damage, it does effectively ensure that the e…
Short Reprogramming of Vascular Endothelium Reduces Blood Pressure in Hypertensive Mice
Reprogramming occurs in the early embryo, a conversion of adult germ cells into embryonic stem cells mediated by expression of the Yamanaka factors – canonically Oct3/4, Sox2, Klf4, and c-Myc. This is accompanied by a reset of age-related changes in gene expression, and a clearing out of cell damage and dysfunction. This process cannot fix everything, but in conjunction with the ability to selectively sacrifice embryonic cells with too great a burden of molecular damage, it does effectively ensure that the e…