IRAK-M Upregulation as an Approach to Slow the Progression of Macular Degeneration

Source https://www.fightaging.org/archives/2024/06/irak-m-upregulation-as-an-approach-to-slow-the-progression-of-macular-degeneration/

Researchers here report that the IRAK-M protein is protective of retinal cell health, but the amount of IRAK-M expressed in the retina declines with age. This may be due to the increased oxidative stress that is characteristic of aged tissues. Gene therapy to increase IRAK-M expression appears to slow the progression of damage and loss of function in the retina in mice, at least in the models tested. It remains to be seen as to whether this will hold up in the condition itself.

Progression of age-related macular degeneration (AMD) affects around 200-million people worldwide. Patients suffering from AMD often …

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