Source https://www.fightaging.org/archives/2024/06/more-on-pi3k-inhibitors-as-senolytic-drugs/
Senolytic drugs selectively clear senescent cells from aged tissues. They are variably effective in different stages of cellular senescence, origins of cellular senescence, and tissue types, as senescent cells vary widely in the details of their biochemistry. We might expect a near future clinical marketplace to feature a dozen or more senolytic therapies, each of which is tailored to specific circumstances and age-related conditions. One of the interesting use cases is to destroy the senescent cancer cells that remain in the body after chemotherapy and other forms of cancer treatment. This will likely require somewhat different senolytics from those used to clear cells …
Source https://www.fightaging.org/archives/2024/06/more-on-pi3k-inhibitors-as-senolytic-drugs/
Senolytic drugs selectively clear senescent cells from aged tissues. They are variably effective in different stages of cellular senescence, origins of cellular senescence, and tissue types, as senescent cells vary widely in the details of their biochemistry. We might expect a near future clinical marketplace to feature a dozen or more senolytic therapies, each of which is tailored to specific circumstances and age-related conditions. One of the interesting use cases is to destroy the senescent cancer cells that remain in the body after chemotherapy and other forms of cancer treatment. This will likely require somewhat different senolytics from those used to clear cells …
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