The blood-brain barrier is a layer of specialized cells that only very selectively allow passage of molecules and cells to and from blood vessels that pass through the brain. The barrier separates the biochemistry of the brain from that of the rest of the body. Unfortunately, the blood-brain barrier becomes dysfunctional with age, allowing leakage of unwanted molecules and cells into the brain, where they can, for example, provoke chronic inflammatory behavior in innate immune cells and other supporting cell populations responsible for maintaining brain tissue. It is presen…
Correlating Regional Blood-Brain Barrier Dysfunction with Alzheimer's Disease Biomarkers
The blood-brain barrier is a layer of specialized cells that only very selectively allow passage of molecules and cells to and from blood vessels that pass through the brain. The barrier separates the biochemistry of the brain from that of the rest of the body. Unfortunately, the blood-brain barrier becomes dysfunctional with age, allowing leakage of unwanted molecules and cells into the brain, where they can, for example, provoke chronic inflammatory behavior in innate immune cells and other supporting cell populations responsible for maintaining brain tissue. It is presen…