Source https://www.fightaging.org/archives/2024/06/lower-ceremide-levels-in-aged-ghrh-knockout-mice/
GHRH knockout mice are one of the longest-lived lineages. It remains the case that disrupted growth hormone signaling extends life to a greater degree than any of the other interventions tested in mice. The equivalent Laron syndrome population in humans clearly doesn’t experience the same sizable extension of life span, however. This should perhaps tell us that researchers must look elsewhere for approaches to the treatment of aging in long-lived mammals. The most well studied approaches to extend healthy life span in mice, meaning calorie restriction and disruption of growth hormone signaling, do not improve human life span to anywhere near the same degree.
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Source https://www.fightaging.org/archives/2024/06/lower-ceremide-levels-in-aged-ghrh-knockout-mice/
GHRH knockout mice are one of the longest-lived lineages. It remains the case that disrupted growth hormone signaling extends life to a greater degree than any of the other interventions tested in mice. The equivalent Laron syndrome population in humans clearly doesn’t experience the same sizable extension of life span, however. This should perhaps tell us that researchers must look elsewhere for approaches to the treatment of aging in long-lived mammals. The most well studied approaches to extend healthy life span in mice, meaning calorie restriction and disruption of growth hormone signaling, do not improve human life span to anywhere near the same degree.
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