Hematopoietic cell populations of various types differentiated from hematopoietic stem cells reside in the bone marrow and are responsible for creating blood and immune cells. Hematopoietic stem cells become dysfunctional with advancing age, as is true of all stem cell populations. The proximate causes of this dysfunction are likely different for every type of stem cell, however. Of the stem cell populations that are well-researched, some remain fully functional in principle but become increasingly quiescent. Others suffer a…
Declining KITL and IGF-1 Signaling in the Aging Hematopoietic Stem Cell Niche
Hematopoietic cell populations of various types differentiated from hematopoietic stem cells reside in the bone marrow and are responsible for creating blood and immune cells. Hematopoietic stem cells become dysfunctional with advancing age, as is true of all stem cell populations. The proximate causes of this dysfunction are likely different for every type of stem cell, however. Of the stem cell populations that are well-researched, some remain fully functional in principle but become increasingly quiescent. Others suffer a…