Towards a Protein Aggregation Clock for Biological Age

Source https://www.fightaging.org/archives/2024/06/towards-a-protein-aggregation-clock-for-biological-age/

There are many ways to construct a measure of biological age. Any form of complex data that varies over the course of aging will suffice. Machine learning can determine algorithmic combinations of measured values that correlate with age, and then one can assess the biological age of an individual by seeing where they fit into the established trend. Here, researchers advocate for the use of protein aggregate levels as the underlying data upon which to build a clock. Many different proteins can aggregate with advancing age, and tend to do so to a greater degree in later life, so this data could be used to build novel clocks with which to measure biological age.

As we age, the DNA and proteins that make up our bodies gradually under…

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