A Mechanism for Developmental Programming to Contribute to Degenerative Aging

Source https://www.fightaging.org/archives/2024/07/a-mechanism-for-developmental-programming-to-contribute-to-degenerative-aging/

The consensus view of the evolution of aging is that it is a consequence of selection pressure for reproductive fitness operating more strongly in early life. This allows for the selection of cellular biochemistry that works well in youth but malfunctions in later life. The more specific and less widely held hyperfunction or quasi-programmed view of aging envisages degenerative aging as a consequence of the continued activity of developmental programs. It is interesting to here see researchers proposing a specific hyperfunction-like mechanism for dysfunction in aging, linking reactivation of developmental gene expression regulation to aging.

A mec…

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