A Glance at the Work of Calico Labs on the Integrated Stress Response

Source https://www.fightaging.org/archives/2024/11/a-glance-at-the-work-of-calico-labs-on-the-integrated-stress-response/

The work conducted at Calico Labs is representative of the broad faction of the aging research community that aims to alter metabolism in order to modestly slow the progression of aging. The damaged and dysfunctional environment of aged tissues and cell structures produces cell stress via many different mechanisms. Cells respond to that stress in a smaller set of ways, and some of those responses are maladaptive, making the situation worse. The best way forward would be to repair the damage that causes cell stress; the approach taken here is to instead alter the behavior of cells in order to selectively sabotage some of the maladaptive response to cell stress.

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Source https://www.fightaging.org/archives/2024/11/a-glance-at-the-work-of-calico-labs-on-the-integrated-stress-response/

The work conducted at Calico Labs is representative of the broad faction of the aging research community that aims to alter metabolism in order to modestly slow the progression of aging. The damaged and dysfunctional environment of aged tissues and cell structures produces cell stress via many different mechanisms. Cells respond to that stress in a smaller set of ways, and some of those responses are maladaptive, making the situation worse. The best way forward would be to repair the damage that causes cell stress; the approach taken here is to instead alter the behavior of cells in order to selectively sabotage some of the maladaptive response to cell stress.

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