Senolytics Don't Help Aged Mice Resist Influenza Infection

Source https://www.fightaging.org/archives/2025/01/senolytics-dont-help-aged-mice-resist-influenza-infection/

In mice, senolytic therapies to clear senescent cells seem such a panacea for age-related conditions that it is always interesting to see evidence for an aspect of aging that is not helped by removal of a portion of the burden of lingering senescent cells. Here, researchers show that senolytics do nothing to help aged mice resist influenza infection if they are administered during or shortly before exposure. Based on what is known of the role of cellular senescence in aging, one would expect an aged mouse that has been treated once with senolytics to later be more resilient to stresses of all sorts, but it likely takes some time for the benefits to be realized, longer than was allowed for here.

Aging is a major risk factor…

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