Does Air Pollution Contribute Meaningfully to Iron Accumulation in the Aging Brain?

Source https://www.fightaging.org/archives/2025/05/does-air-pollution-contribute-meaningfully-to-iron-accumulation-in-the-aging-brain/

The consensus on air pollution is that it increases late life mortality, largely via an increase in chronic inflammation in exposed tissues in the lung. Researchers here propose that uptake of iron from inhaled particulate matter can contribute to the age-related increase of iron that takes place in the brain, and thus cause pathology. The researchers demonstrate that this introduction of iron from airborne pollutants into the brain can occur in mice, but the question (as usual) is whether in humans this has an effect size large enough to be important versus the inflammatory consequences of air pollution.

Both excess brain iron (Fe) and air pollution (AP) exposures are associated with increased risk for mul…

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