Source https://www.fightaging.org/archives/2025/06/evidence-against-mitochondrial-mutator-mice-as-support-for-the-importance-of-mitochondrial-dna-damage/
One of the major challenges in aging research is establishing the relative importance of the various well-known different mechanisms, hallmarks, and dysfunctions of aging. This is large part because biological systems and their relationships to one another are not fully mapped and understood at the detail level. Mitochondrial dysfunction is a great example; mitochondria are enormously complex, and even very important processes such as mitophagy are not completely understood in detail. Thus there is considerable debate over the importance of mitochondrial DNA damage to aging.
One of the pillars of supporting ev…
Source https://www.fightaging.org/archives/2025/06/evidence-against-mitochondrial-mutator-mice-as-support-for-the-importance-of-mitochondrial-dna-damage/
One of the major challenges in aging research is establishing the relative importance of the various well-known different mechanisms, hallmarks, and dysfunctions of aging. This is large part because biological systems and their relationships to one another are not fully mapped and understood at the detail level. Mitochondrial dysfunction is a great example; mitochondria are enormously complex, and even very important processes such as mitophagy are not completely understood in detail. Thus there is considerable debate over the importance of mitochondrial DNA damage to aging.
One of the pillars of supporting ev…
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