One might view this paper as a companion to a recent discussion of the greater vulnerability of the aged brain to amyloid-β toxicity. Here, researchers point out the dysregulation of RNA splicing in aged neurons, and note its contribution to a greater vulnerability to forms of cell stress. Degenerative aging is formed of many contributions, and every perturbation in normal cell metabolism leaves cells vulnerable to other forms of change and damage. It builds upon itself, degrading function, until some major catastrophe results, both at the level of individual cells and their survival, and at the level of tissues and organs. Addressing the dysregulation of RNA splicing is the subject of a few programs …
Aged Neurons Exhibit Dysregulated RNA Processing and are More Vulnerable to Stress
One might view this paper as a companion to a recent discussion of the greater vulnerability of the aged brain to amyloid-β toxicity. Here, researchers point out the dysregulation of RNA splicing in aged neurons, and note its contribution to a greater vulnerability to forms of cell stress. Degenerative aging is formed of many contributions, and every perturbation in normal cell metabolism leaves cells vulnerable to other forms of change and damage. It builds upon itself, degrading function, until some major catastrophe results, both at the level of individual cells and their survival, and at the level of tissues and organs. Addressing the dysregulation of RNA splicing is the subject of a few programs …