Source https://www.fightaging.org/archives/2025/06/the-healthspan-proteomic-score/
The research community continues to create aging clocks based on omics data at a fair pace. At this point, there are scores of clocks one might chose from if conducting studies on potential therapies to slow or reverse aspects of aging. Yet the primary challenge remains knowing whether any given clock will accurately reflect future outcomes following a specific form of treatment, meaning reduced risk of age-related disease and lowered mortality. Because there is no detailed map linking the omics data making up a clock to underlying mechanisms of aging or outcomes in aging, researchers do not know in advance how an aging clock will react to changes in the mechanisms targeted by a potential treatment for aging, and whether those reactions are useful. The clock might overestimate the impact, it might underestimate the impact. The only way to find out in certainty is to calibrate the clo…
Source https://www.fightaging.org/archives/2025/06/the-healthspan-proteomic-score/
The research community continues to create aging clocks based on omics data at a fair pace. At this point, there are scores of clocks one might chose from if conducting studies on potential therapies to slow or reverse aspects of aging. Yet the primary challenge remains knowing whether any given clock will accurately reflect future outcomes following a specific form of treatment, meaning reduced risk of age-related disease and lowered mortality. Because there is no detailed map linking the omics data making up a clock to underlying mechanisms of aging or outcomes in aging, researchers do not know in advance how an aging clock will react to changes in the mechanisms targeted by a potential treatment for aging, and whether those reactions are useful. The clock might overestimate the impact, it might underestimate the impact. The only way to find out in certainty is to calibrate the clo…
What Do You Think?
comments