Cell reprogramming as a basis for the treatment of aging involves inducing the expression of Yamanaka factors for a short period of time, ideally resulting in a shift in cell epigenetic state to a more youthful configuration without disruption of cell function or the creation of potentially harmful pluripotent stem cells. While early efforts focused on gene therapy technologies, there is a branch of research focused on small molecules that might achieve sufficient Yamanaka factor expression to be interesting. A number of combinations of small molecules have been explored, an…
Small Molecule Reprogramming in Mice with RepSox and Tranylcypromine
Cell reprogramming as a basis for the treatment of aging involves inducing the expression of Yamanaka factors for a short period of time, ideally resulting in a shift in cell epigenetic state to a more youthful configuration without disruption of cell function or the creation of potentially harmful pluripotent stem cells. While early efforts focused on gene therapy technologies, there is a branch of research focused on small molecules that might achieve sufficient Yamanaka factor expression to be interesting. A number of combinations of small molecules have been explored, an…