Prostaglandin E2 Delivery Improves Stem Cell Function in Aged Muscle

Source https://www.fightaging.org/archives/2025/06/prostaglandin-e2-delivery-improves-stem-cell-function-in-aged-muscle/

Researchers here focus on a signaling mechanism that is diminished with age, the interaction between circulating prostaglandin E2 (PGE2) and its receptor EP4 on muscle stem cells. Levels of both PGE2 and its receptor decline with age, and this appears to broadly impair muscle stem cell function. The proof of that point is that delivering more PGE2 to aged mice improves muscle stem cell function, leading to an improved response following muscle injury.

Researchers examined the effects of circulating prostaglandin E2 (PGE2) and its receptor EP4 on muscle tissue. Their prior research had established that PGE2 signals during muscle injury trigger muscle stem cells to regenerate the muscles of youn…

What Do You Think?

comments