Source https://www.fightaging.org/archives/2025/07/a-novel-approach-to-thermogenesis-without-involving-uncoupling-protein-1/
Mitochondrial uncoupling is the process by which mitochondria in cells switch from producing the chemical energy store molecule adenosine triphosphate (ATP) to releasing that energy as heat. This is of interest in the context of aging because upregulation of mitochondrial uncoupling via a range of strategies appears to somewhat slow aging in animal studies. Sustained upregulation of mitochondrial uncoupling also produces a reduction in fat tissue and weight loss. Humans being humans, there is considerably more interest in that outcome than in effects on aging, particularly now that weight loss drugs have become a large revenue source for the major pharma companies.
Historically, researchers have struggled to produce mitochondrial uncoupling drugs that will not kill people through ov…
Source https://www.fightaging.org/archives/2025/07/a-novel-approach-to-thermogenesis-without-involving-uncoupling-protein-1/
Mitochondrial uncoupling is the process by which mitochondria in cells switch from producing the chemical energy store molecule adenosine triphosphate (ATP) to releasing that energy as heat. This is of interest in the context of aging because upregulation of mitochondrial uncoupling via a range of strategies appears to somewhat slow aging in animal studies. Sustained upregulation of mitochondrial uncoupling also produces a reduction in fat tissue and weight loss. Humans being humans, there is considerably more interest in that outcome than in effects on aging, particularly now that weight loss drugs have become a large revenue source for the major pharma companies.
Historically, researchers have struggled to produce mitochondrial uncoupling drugs that will not kill people through ov…
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