ALDH1A2 Overexpression Enables Ear Tissue Regeneration in Mice

Source https://www.fightaging.org/archives/2025/07/aldh1a2-overexpression-enables-ear-tissue-regeneration-in-mice/

In today’s open access paper, researchers argue that the regeneration of outer, visible ear tissue is a useful area of focus for understanding why mammals are limited in their regenerative capacity. Species such as salamanders and zebrafish can regenerate limbs and internal organs, and researchers would like to understand how to enable this capability in mammals. The ear is interesting in this respect because some mammals are capable of regeneration of ear tissue, while others are not, giving a starting point for a closer comparison of the relevant biochemistry between more similar species. Mice are incapable of ear tissue regeneration, which is why ear notching is a common means of animal identification used in laboratories. Interestingly, this is how the <a href="https://www.fightaging.org/archives/2015/06/…

Source https://www.fightaging.org/archives/2025/07/aldh1a2-overexpression-enables-ear-tissue-regeneration-in-mice/

In today’s open access paper, researchers argue that the regeneration of outer, visible ear tissue is a useful area of focus for understanding why mammals are limited in their regenerative capacity. Species such as salamanders and zebrafish can regenerate limbs and internal organs, and researchers would like to understand how to enable this capability in mammals. The ear is interesting in this respect because some mammals are capable of regeneration of ear tissue, while others are not, giving a starting point for a closer comparison of the relevant biochemistry between more similar species. Mice are incapable of ear tissue regeneration, which is why ear notching is a common means of animal identification used in laboratories. Interestingly, this is how the <a href="https://www.fightaging.org/archives/2015/06/…

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