A Bidirectional Relationship Between Aging and Fibrotic Liver Disease

Source https://www.fightaging.org/archives/2025/08/a-bidirectional-relationship-between-aging-and-fibrotic-liver-disease/

Metabolic dysfunction-associated steatohepatitis (MASH) follows a fatty liver, largely a consequence of obesity, but made worse by aging, in which fat-induced dysfunction of liver tissue maintenance leads to an increasing burden of fibrosis and loss of function. In fibrosis, the normal mechanisms of tissue maintenance run awry and excessive collagen is deposited to form scar-like structures that disrupt tissue function. At present fibrosis is largely irreversible, despite some potentially promising lines of research and development.

In recent years, aging and cellular senescence have triggered an increased interest in correspondi…

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