The Relevance of Long-Lived Molecules to Aging Remains Speculative

Source https://www.fightaging.org/archives/2025/08/the-relevance-of-long-lived-molecules-to-aging-remains-speculative/

Some long-lived proteins (such as components of nuclear pore structures) in some long-lived cells (such as neurons) may never be replaced across a normal life span, or at the very least have lifetimes of years. That suggests that damage to these molecules may be important in aging and age-related disease. Some research has taken place on this topic, but as noted here, issues of measurement ensure that damage to long-lived molecules remains a more speculative contribution to degenerative aging. It may be important relative to other mechanisms, or it may not.

Neurons, unlike most other cell types, do not divide and are not replaced ov…

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