Microglial Dysfunction and Cholesterol Metabolism Dysregulation in the Aging Brain

Source https://www.fightaging.org/archives/2025/09/microglial-dysfunction-and-cholesterol-metabolism-dysregulation-in-the-aging-brain/

Researchers studying neurodegenerative conditions have increasingly focused on the role of microglia in recent years. Microglia are innate immune cells analogous to the macrophages found in the rest of the body. They undertake a broad range of tasks including defense against pathogens, destruction of malfunctioning cells, coordination of tissue maintenance and regeneration, and assisting in alterations to the networks of synaptic connections between neurons necessary for the function of the brain. With age, some microglia <a href="https://www.fightaging.org/archives/2022/07/microglia-in-the-aging…

Source https://www.fightaging.org/archives/2025/09/microglial-dysfunction-and-cholesterol-metabolism-dysregulation-in-the-aging-brain/

Researchers studying neurodegenerative conditions have increasingly focused on the role of microglia in recent years. Microglia are innate immune cells analogous to the macrophages found in the rest of the body. They undertake a broad range of tasks including defense against pathogens, destruction of malfunctioning cells, coordination of tissue maintenance and regeneration, and assisting in alterations to the networks of synaptic connections between neurons necessary for the function of the brain. With age, some microglia <a href="https://www.fightaging.org/archives/2022/07/microglia-in-the-aging…

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