The Hippo pathway shows up in many areas of research into aging, regeneration, cancer, and cellular senescence. This tends to be the case for protein machinery that is involved in cell growth and cell stress responses, including programmed cell death. See the research surrounding nutrient signaling and its relationship with cell growth, centering around mTOR and its surrounding biochemistry, for example. Hippo signaling is fairly complex, but also quite well explored. Nonetheless while individual protein interactions in the pathway are well mapped, how it operates in detail to produce different outcomes in different contexts is less well understood. It…
Hippo Pathway Inhibition Provides Resistance to Ferroptosis in the Aging Brain
The Hippo pathway shows up in many areas of research into aging, regeneration, cancer, and cellular senescence. This tends to be the case for protein machinery that is involved in cell growth and cell stress responses, including programmed cell death. See the research surrounding nutrient signaling and its relationship with cell growth, centering around mTOR and its surrounding biochemistry, for example. Hippo signaling is fairly complex, but also quite well explored. Nonetheless while individual protein interactions in the pathway are well mapped, how it operates in detail to produce different outcomes in different contexts is less well understood. It…