Lower Circulating BDNF Level Correlates with Greater Cognitive Decline

Source https://www.fightaging.org/archives/2025/10/lower-circulating-bdnf-level-correlates-with-greater-cognitive-decline/

A range of research suggests that an increase in the circulating levels of BDNF is beneficial to the function of the brain (and likely muscle tissue as well). This is one of the ways in which alterations to the diet and gut microbiome composition can affect the brain, as microbial production of butyrate via fermentation of dietary fiber acts to increase BDNF expression. The research community has an interest in finding other ways to increase BDNF levels more directly, and that is a work in progress. Meanwhile, researchers continue to produce evidence t…

Source https://www.fightaging.org/archives/2025/10/lower-circulating-bdnf-level-correlates-with-greater-cognitive-decline/

A range of research suggests that an increase in the circulating levels of BDNF is beneficial to the function of the brain (and likely muscle tissue as well). This is one of the ways in which alterations to the diet and gut microbiome composition can affect the brain, as microbial production of butyrate via fermentation of dietary fiber acts to increase BDNF expression. The research community has an interest in finding other ways to increase BDNF levels more directly, and that is a work in progress. Meanwhile, researchers continue to produce evidence t…

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