Source https://www.fightaging.org/archives/2025/09/targeting-aspects-of-aging-with-immunotherapy-technologies/
Immunotherapy is a broad label, encompassing a range of approaches that include varieties of vaccination, selective interference in immune signaling, delivery of engineered immune cells, gene therapies capable of adjusting the behavior of immune cells, and more. An aging-focused viewpoint might also add the destruction of senescent cells or alteration of senescent cell signaling behavior, given the detrimental effect that senescent cell signaling produces on the <a href="https://en.wikipedia.org/wiki/Imm…
Source https://www.fightaging.org/archives/2025/09/targeting-aspects-of-aging-with-immunotherapy-technologies/
Immunotherapy is a broad label, encompassing a range of approaches that include varieties of vaccination, selective interference in immune signaling, delivery of engineered immune cells, gene therapies capable of adjusting the behavior of immune cells, and more. An aging-focused viewpoint might also add the destruction of senescent cells or alteration of senescent cell signaling behavior, given the detrimental effect that senescent cell signaling produces on the <a href="https://en.wikipedia.org/wiki/Imm…
Source https://tinybuddha.com/blog/the-power-i-now-carry-because-of-my-illness/
“Whatever the present moment contains, accept it as if you had chosen it. Always work with it, not against it.” ~Eckhart Tolle
For years, I thought strength meant pushing through. Getting on with it. Holding it together no matter what. Not showing weakness. Not needing help. Not slowing down.
Even when I was diagnosed with a chronic illness, I wore that mindset like armor. I was determined not to let it define me—let alone derail me.
But eventually, it did. Not because I was weak. But because I was human. And that was the beginning of a different kind of strength.
<h3 st…
Source https://tinybuddha.com/blog/the-power-i-now-carry-because-of-my-illness/
“Whatever the present moment contains, accept it as if you had chosen it. Always work with it, not against it.” ~Eckhart Tolle
For years, I thought strength meant pushing through. Getting on with it. Holding it together no matter what. Not showing weakness. Not needing help. Not slowing down.
Even when I was diagnosed with a chronic illness, I wore that mindset like armor. I was determined not to let it define me—let alone derail me.
But eventually, it did. Not because I was weak. But because I was human. And that was the beginning of a different kind of strength.
<h3 st…
Source https://www.fightaging.org/archives/2025/09/fight-aging-newsletter-september-29th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
Source https://www.fightaging.org/archives/2025/09/fight-aging-newsletter-september-29th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
Source https://www.fightaging.org/archives/2025/09/resistance-training-improves-peripheral-nerve-function-in-older-adults/
Regular exercise is demonstrated to improve many aspects of health in a dose-dependent fashion. Aerobic exercise and resistance exercise have overlapping but subtly different effects, and are often studied distinctly. Program of resistance exercise have been demonstrated to reduce mortality in older individuals, and more generally the view of “use it or lose it” is supported by the scientific literature. Exercise produces benefits, and a sedentary life is harmful to long-term health. Here, researchers demonstrate that the benefits of exercise in older individuals include improved peripheral nerve function.
<blockqu…
Source https://www.fightaging.org/archives/2025/09/resistance-training-improves-peripheral-nerve-function-in-older-adults/
Regular exercise is demonstrated to improve many aspects of health in a dose-dependent fashion. Aerobic exercise and resistance exercise have overlapping but subtly different effects, and are often studied distinctly. Program of resistance exercise have been demonstrated to reduce mortality in older individuals, and more generally the view of “use it or lose it” is supported by the scientific literature. Exercise produces benefits, and a sedentary life is harmful to long-term health. Here, researchers demonstrate that the benefits of exercise in older individuals include improved peripheral nerve function.
<blockqu…
Source https://www.fightaging.org/archives/2025/09/applying-mendelian-randomization-to-support-a-causal-relationship-between-frailty-and-dementia/
Mining human epidemiological data can only produce correlations. Mendelian randomization is a way to add data on genetic variants known to affect disease status into the mix so as to add some support for causation. The result isn’t a determination of causation, but in the best case is supportive of that conclusion. Physical frailty is well known to correlate with neurodegeneration, and a range of reasonable hypotheses exist to explain why this is the case. Both emerge from chronic inflammation and other underlying dysfunctions of aging, for example. Or frailty involves significant dysfunction in the <a href="https://en.wiki…
Source https://www.fightaging.org/archives/2025/09/applying-mendelian-randomization-to-support-a-causal-relationship-between-frailty-and-dementia/
Mining human epidemiological data can only produce correlations. Mendelian randomization is a way to add data on genetic variants known to affect disease status into the mix so as to add some support for causation. The result isn’t a determination of causation, but in the best case is supportive of that conclusion. Physical frailty is well known to correlate with neurodegeneration, and a range of reasonable hypotheses exist to explain why this is the case. Both emerge from chronic inflammation and other underlying dysfunctions of aging, for example. Or frailty involves significant dysfunction in the <a href="https://en.wiki…
Source https://tinybuddha.com/blog/the-truth-about-my-inner-critic-it-was-trauma-talking/
“I will not let the bullies and critics of my early life win by joining and agreeing with them.” ~Pete Walker
For most of my life, there was a voice in my head that narrated everything I did, and it was kind of an a**hole.
You know the one. That voice that jumps in before you even finish a thought:
“Don’t say that. You’ll sound stupid.”
“Why would anyone care what you think?”
“You’re too much. You’re not enough. You’re a mess.”
No matter what I did, the critic had notes. Brutal ones. And the worst part? I believed every word. I didn’t know it was a critic. I thought I just ha…
Source https://tinybuddha.com/blog/the-truth-about-my-inner-critic-it-was-trauma-talking/
“I will not let the bullies and critics of my early life win by joining and agreeing with them.” ~Pete Walker
For most of my life, there was a voice in my head that narrated everything I did, and it was kind of an a**hole.
You know the one. That voice that jumps in before you even finish a thought:
“Don’t say that. You’ll sound stupid.”
“Why would anyone care what you think?”
“You’re too much. You’re not enough. You’re a mess.”
No matter what I did, the critic had notes. Brutal ones. And the worst part? I believed every word. I didn’t know it was a critic. I thought I just ha…
Source https://www.fightaging.org/archives/2025/09/betaine-as-an-exercise-mimetic/
Exercise has been shown to induce the synthesis of the metabolite betaine (trimethylglycine) in the kidneys. Separately, delivery of betaine was developed as a therapy for the rare disease homocystinuria due to its ability to blunt the harmful buildup of homocysteine in that condition. Here, researchers briefly review recent developments in the understanding of the ability of additional betaine delivered as a therapy to act as an exercise mimetic, triggering some of the beneficial metabolic responses to exercise.
Recently, researchers identified the <a href="https:/…
Source https://www.fightaging.org/archives/2025/09/betaine-as-an-exercise-mimetic/
Exercise has been shown to induce the synthesis of the metabolite betaine (trimethylglycine) in the kidneys. Separately, delivery of betaine was developed as a therapy for the rare disease homocystinuria due to its ability to blunt the harmful buildup of homocysteine in that condition. Here, researchers briefly review recent developments in the understanding of the ability of additional betaine delivered as a therapy to act as an exercise mimetic, triggering some of the beneficial metabolic responses to exercise.
Recently, researchers identified the <a href="https:/…
Source https://www.fightaging.org/archives/2025/09/reviewing-the-role-of-mtor-in-aging/
The mechanistic (or mammalian) target of rapamycin (mTOR) is a well studied portion of cellular biochemistry. The activity of mTOR and downstream consequences of that activity form one portion of a broad regulatory system that reacts to nutrient availability in order to change growth and stress responses in cells. Inhibition of mTOR is a necessary part of the beneficial response to fasting and calorie restriction, in which an increase in the activity of cell maintenance processes acts to improve health and slow the progression of aging. Animal studies robustly demonstrate extended lifespan in response to mTOR inhibition. In recent years a number of pr…
Source https://www.fightaging.org/archives/2025/09/reviewing-the-role-of-mtor-in-aging/
The mechanistic (or mammalian) target of rapamycin (mTOR) is a well studied portion of cellular biochemistry. The activity of mTOR and downstream consequences of that activity form one portion of a broad regulatory system that reacts to nutrient availability in order to change growth and stress responses in cells. Inhibition of mTOR is a necessary part of the beneficial response to fasting and calorie restriction, in which an increase in the activity of cell maintenance processes acts to improve health and slow the progression of aging. Animal studies robustly demonstrate extended lifespan in response to mTOR inhibition. In recent years a number of pr…