Source https://www.fightaging.org/archives/2025/09/resistance-training-improves-peripheral-nerve-function-in-older-adults/
Regular exercise is demonstrated to improve many aspects of health in a dose-dependent fashion. Aerobic exercise and resistance exercise have overlapping but subtly different effects, and are often studied distinctly. Program of resistance exercise have been demonstrated to reduce mortality in older individuals, and more generally the view of “use it or lose it” is supported by the scientific literature. Exercise produces benefits, and a sedentary life is harmful to long-term health. Here, researchers demonstrate that the benefits of exercise in older individuals include improved peripheral nerve function.
<blockqu…
Source https://www.fightaging.org/archives/2025/09/resistance-training-improves-peripheral-nerve-function-in-older-adults/
Regular exercise is demonstrated to improve many aspects of health in a dose-dependent fashion. Aerobic exercise and resistance exercise have overlapping but subtly different effects, and are often studied distinctly. Program of resistance exercise have been demonstrated to reduce mortality in older individuals, and more generally the view of “use it or lose it” is supported by the scientific literature. Exercise produces benefits, and a sedentary life is harmful to long-term health. Here, researchers demonstrate that the benefits of exercise in older individuals include improved peripheral nerve function.
<blockqu…
Source https://www.fightaging.org/archives/2025/09/applying-mendelian-randomization-to-support-a-causal-relationship-between-frailty-and-dementia/
Mining human epidemiological data can only produce correlations. Mendelian randomization is a way to add data on genetic variants known to affect disease status into the mix so as to add some support for causation. The result isn’t a determination of causation, but in the best case is supportive of that conclusion. Physical frailty is well known to correlate with neurodegeneration, and a range of reasonable hypotheses exist to explain why this is the case. Both emerge from chronic inflammation and other underlying dysfunctions of aging, for example. Or frailty involves significant dysfunction in the <a href="https://en.wiki…
Source https://www.fightaging.org/archives/2025/09/applying-mendelian-randomization-to-support-a-causal-relationship-between-frailty-and-dementia/
Mining human epidemiological data can only produce correlations. Mendelian randomization is a way to add data on genetic variants known to affect disease status into the mix so as to add some support for causation. The result isn’t a determination of causation, but in the best case is supportive of that conclusion. Physical frailty is well known to correlate with neurodegeneration, and a range of reasonable hypotheses exist to explain why this is the case. Both emerge from chronic inflammation and other underlying dysfunctions of aging, for example. Or frailty involves significant dysfunction in the <a href="https://en.wiki…
Source https://tinybuddha.com/blog/the-truth-about-my-inner-critic-it-was-trauma-talking/
“I will not let the bullies and critics of my early life win by joining and agreeing with them.” ~Pete Walker
For most of my life, there was a voice in my head that narrated everything I did, and it was kind of an a**hole.
You know the one. That voice that jumps in before you even finish a thought:
“Don’t say that. You’ll sound stupid.”
“Why would anyone care what you think?”
“You’re too much. You’re not enough. You’re a mess.”
No matter what I did, the critic had notes. Brutal ones. And the worst part? I believed every word. I didn’t know it was a critic. I thought I just ha…
Source https://tinybuddha.com/blog/the-truth-about-my-inner-critic-it-was-trauma-talking/
“I will not let the bullies and critics of my early life win by joining and agreeing with them.” ~Pete Walker
For most of my life, there was a voice in my head that narrated everything I did, and it was kind of an a**hole.
You know the one. That voice that jumps in before you even finish a thought:
“Don’t say that. You’ll sound stupid.”
“Why would anyone care what you think?”
“You’re too much. You’re not enough. You’re a mess.”
No matter what I did, the critic had notes. Brutal ones. And the worst part? I believed every word. I didn’t know it was a critic. I thought I just ha…
Source https://www.fightaging.org/archives/2025/09/betaine-as-an-exercise-mimetic/
Exercise has been shown to induce the synthesis of the metabolite betaine (trimethylglycine) in the kidneys. Separately, delivery of betaine was developed as a therapy for the rare disease homocystinuria due to its ability to blunt the harmful buildup of homocysteine in that condition. Here, researchers briefly review recent developments in the understanding of the ability of additional betaine delivered as a therapy to act as an exercise mimetic, triggering some of the beneficial metabolic responses to exercise.
Recently, researchers identified the <a href="https:/…
Source https://www.fightaging.org/archives/2025/09/betaine-as-an-exercise-mimetic/
Exercise has been shown to induce the synthesis of the metabolite betaine (trimethylglycine) in the kidneys. Separately, delivery of betaine was developed as a therapy for the rare disease homocystinuria due to its ability to blunt the harmful buildup of homocysteine in that condition. Here, researchers briefly review recent developments in the understanding of the ability of additional betaine delivered as a therapy to act as an exercise mimetic, triggering some of the beneficial metabolic responses to exercise.
Recently, researchers identified the <a href="https:/…
Source https://www.fightaging.org/archives/2025/09/reviewing-the-role-of-mtor-in-aging/
The mechanistic (or mammalian) target of rapamycin (mTOR) is a well studied portion of cellular biochemistry. The activity of mTOR and downstream consequences of that activity form one portion of a broad regulatory system that reacts to nutrient availability in order to change growth and stress responses in cells. Inhibition of mTOR is a necessary part of the beneficial response to fasting and calorie restriction, in which an increase in the activity of cell maintenance processes acts to improve health and slow the progression of aging. Animal studies robustly demonstrate extended lifespan in response to mTOR inhibition. In recent years a number of pr…
Source https://www.fightaging.org/archives/2025/09/reviewing-the-role-of-mtor-in-aging/
The mechanistic (or mammalian) target of rapamycin (mTOR) is a well studied portion of cellular biochemistry. The activity of mTOR and downstream consequences of that activity form one portion of a broad regulatory system that reacts to nutrient availability in order to change growth and stress responses in cells. Inhibition of mTOR is a necessary part of the beneficial response to fasting and calorie restriction, in which an increase in the activity of cell maintenance processes acts to improve health and slow the progression of aging. Animal studies robustly demonstrate extended lifespan in response to mTOR inhibition. In recent years a number of pr…
Source https://www.fightaging.org/archives/2025/09/valine-restriction-extends-life-span-in-male-mice-only/
Dietary protein refers to the intake of the nine essential amino acids that cannot be synthesized by our biochemistry: valine, isoleucine, leucine, methionine, phenylalanine, tryptophan, threonine, histidine, and lysine. The single value for “protein” that regulators such as the FDA required to be provided on food packaging is d…
Source https://www.fightaging.org/archives/2025/09/valine-restriction-extends-life-span-in-male-mice-only/
Dietary protein refers to the intake of the nine essential amino acids that cannot be synthesized by our biochemistry: valine, isoleucine, leucine, methionine, phenylalanine, tryptophan, threonine, histidine, and lysine. The single value for “protein” that regulators such as the FDA required to be provided on food packaging is d…
Source https://www.theminimalists.com/adtax/
The Minimalists discuss a secret tax being paid by those who can’t afford to opt out.
Do you think advertisements a tax on the poor? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post Advertisements Are a Tax on the Poor appeared first on The Minimalists.
…
Source https://www.theminimalists.com/adtax/
The Minimalists discuss a secret tax being paid by those who can’t afford to opt out.
Do you think advertisements a tax on the poor? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post Advertisements Are a Tax on the Poor appeared first on The Minimalists.
…
Source https://tinybuddha.com/blog/the-surprising-freedom-in-not-having-life-all-figured-out/
“Sometimes you have to let go of the life you planned to make room for the life that’s waiting for you.” ~Joseph Campbell
My new motto? Always have a backup plan.
Life rarely goes as you’d imagined.
January 16th, 2001. That’s the day my life trajectory changed irrevocably. That’s the day that would lead me to, eventually, living alone—to being divorced. That’s the day my ex had a ski accident that changed the lives of every member of our immediate family. But today, I don’t want to talk about him or that. I want to talk about my story, about me. About my aftermath of living alone.
Several years ago, when …
Source https://tinybuddha.com/blog/the-surprising-freedom-in-not-having-life-all-figured-out/
“Sometimes you have to let go of the life you planned to make room for the life that’s waiting for you.” ~Joseph Campbell
My new motto? Always have a backup plan.
Life rarely goes as you’d imagined.
January 16th, 2001. That’s the day my life trajectory changed irrevocably. That’s the day that would lead me to, eventually, living alone—to being divorced. That’s the day my ex had a ski accident that changed the lives of every member of our immediate family. But today, I don’t want to talk about him or that. I want to talk about my story, about me. About my aftermath of living alone.
Several years ago, when …
Source https://tinybuddha.com/blog/why-ai-can-never-replace-us-the-truth-about-being-human/
“AI accidentally made me believe in the concept of a human soul by showing me what art looks like without it.” ~Unknown
What is intelligence?
I’ve asked this question all my life—as a teacher, a filmmaker, a researcher, and now, as someone losing my vision to macular degeneration.
I ask it when I watch students find their voice.
I ask it when I listen to a close friend of mine, a world-renowned cosmologist, whose knowledge seems limitless but whose humility runs even deeper. He can discuss black holes one minute and quote the Tao Te Ching the next. He doesn’t just know facts—he knows how to listen. He knows how to explain something com…
Source https://tinybuddha.com/blog/why-ai-can-never-replace-us-the-truth-about-being-human/
“AI accidentally made me believe in the concept of a human soul by showing me what art looks like without it.” ~Unknown
What is intelligence?
I’ve asked this question all my life—as a teacher, a filmmaker, a researcher, and now, as someone losing my vision to macular degeneration.
I ask it when I watch students find their voice.
I ask it when I listen to a close friend of mine, a world-renowned cosmologist, whose knowledge seems limitless but whose humility runs even deeper. He can discuss black holes one minute and quote the Tao Te Ching the next. He doesn’t just know facts—he knows how to listen. He knows how to explain something com…