Neural Progenitor Cell Transplantation Promotes Recovery Following Stroke in Mice

Source https://www.fightaging.org/archives/2025/09/neural-progenitor-cell-transplantation-promotes-recovery-following-stroke-in-mice/

Researchers here report that human neural progenitor cells derived from induced pluripotent stem cells (iPSCs) can induce some degree of recovery from stroke in mice. As expected for a cell therapy of this nature, functional recovery results from signaling provided by the transplanted cells that favorably alters the behavior of native cells. Inducing regeneration in the brain is important for more than just the damage of stroke, and so is an area of research worth keeping an eye on. In the case of stroke itself, however, more attention should be directed towards prevention: developing means of regressing atherosclerotic plaque to prevent rupture and blockage of vessels in the brain and othe…

Source https://www.fightaging.org/archives/2025/09/neural-progenitor-cell-transplantation-promotes-recovery-following-stroke-in-mice/

Researchers here report that human neural progenitor cells derived from induced pluripotent stem cells (iPSCs) can induce some degree of recovery from stroke in mice. As expected for a cell therapy of this nature, functional recovery results from signaling provided by the transplanted cells that favorably alters the behavior of native cells. Inducing regeneration in the brain is important for more than just the damage of stroke, and so is an area of research worth keeping an eye on. In the case of stroke itself, however, more attention should be directed towards prevention: developing means of regressing atherosclerotic plaque to prevent rupture and blockage of vessels in the brain and othe…

Pillowy Gluten-Free Pita (from Aran Goyoaga’s Cookbook)

Source https://minimalistbaker.com/gluten-free-pita/

Pillowy Gluten-Free Pita (from Aran Goyoaga’s Cookbook)

We’ve long admired the super talented gluten-free chef and baker Aran Goyoaga. But our status went from fans to super fans last year when she posted a video of the fluffiest gluten-free dinner rolls we had ever seen. They looked like fluffy, dreamy clouds — how could they possibly be gluten-free?! We wanted to reach through the screen to make sure they were real (translation: eat the whole pan 🤤).

Then earlier this year, Aran announced she was writing a new cookbook(!!) and we nearly started doing cartwheels.

Pillowy Gluten-Free Pita (from Aran Goyoaga&#82…

Source https://minimalistbaker.com/gluten-free-pita/

Pillowy Gluten-Free Pita (from Aran Goyoaga’s Cookbook)

We’ve long admired the super talented gluten-free chef and baker Aran Goyoaga. But our status went from fans to super fans last year when she posted a video of the fluffiest gluten-free dinner rolls we had ever seen. They looked like fluffy, dreamy clouds — how could they possibly be gluten-free?! We wanted to reach through the screen to make sure they were real (translation: eat the whole pan 🤤).

Then earlier this year, Aran announced she was writing a new cookbook(!!) and we nearly started doing cartwheels.

Pillowy Gluten-Free Pita (from Aran Goyoaga&#82…

Hippo Pathway Inhibition Provides Resistance to Ferroptosis in the Aging Brain

Source https://www.fightaging.org/archives/2025/09/hippo-pathway-inhibition-provides-resistance-to-ferroptosis-in-the-aging-brain/

The Hippo pathway shows up in many areas of research into aging, regeneration, cancer, and cellular senescence. This tends to be the case for protein machinery that is involved in cell growth and cell stress responses, including programmed cell death. See the research surrounding nutrient signaling and its relationship with cell growth, centering around mTOR and its surrounding biochemistry, for example. Hippo signaling is fairly complex, but also quite well explored. Nonetheless while individual protein interactions in the pathway are well mapped, how it operates in detail to produce different outcomes in different contexts is less well understood. It…

Source https://www.fightaging.org/archives/2025/09/hippo-pathway-inhibition-provides-resistance-to-ferroptosis-in-the-aging-brain/

The Hippo pathway shows up in many areas of research into aging, regeneration, cancer, and cellular senescence. This tends to be the case for protein machinery that is involved in cell growth and cell stress responses, including programmed cell death. See the research surrounding nutrient signaling and its relationship with cell growth, centering around mTOR and its surrounding biochemistry, for example. Hippo signaling is fairly complex, but also quite well explored. Nonetheless while individual protein interactions in the pathway are well mapped, how it operates in detail to produce different outcomes in different contexts is less well understood. It…

Podcast Ep. 506 | Capitalism

Source https://www.theminimalists.com/p506/

The Minimalists speak with Rey Flemings about the upsides and downsides of capitalism, potential alternative economic systems, the best ways for wealthy people to be more generous, plus greed, freedom, private ownership, and more.

Listen to the Episode

Apple · Spotify · Patreon

Discussed in This Episode

  • What’s the best way to talk about capitalism objectively without evoking an emotional response?
  • What’s the first thing t…

Source https://www.theminimalists.com/p506/

The Minimalists speak with Rey Flemings about the upsides and downsides of capitalism, potential alternative economic systems, the best ways for wealthy people to be more generous, plus greed, freedom, private ownership, and more.

Listen to the Episode

Apple · Spotify · Patreon

Discussed in This Episode

  • What’s the best way to talk about capitalism objectively without evoking an emotional response?
  • What’s the first thing t…

Lymphatic Success Secrets: How Touch + Tech Transform Wellness

Source https://www.americanspa.com/premium/webinar/206048

Lymphatic Success Secrets: How Touch + Tech Transform Wellness
swheeler
Tue, 09/16/2025 – 17:52

Tue, 10/14/2025 – 13:00

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Promotion Start
Tue, …

Source https://www.americanspa.com/premium/webinar/206048

Lymphatic Success Secrets: How Touch + Tech Transform Wellness
swheeler
Tue, 09/16/2025 – 17:52

Tue, 10/14/2025 – 13:00

Resource Type

Promotion Start
Tue, …

Brilliant, Not Broken: A Powerful Reframe for Neurodivergence

Source https://tinybuddha.com/blog/brilliant-not-broken-a-powerful-reframe-for-neurodivergence/

“It is not our differences that divide us. It is our inability to recognize, accept, and celebrate those differences.” ~Audre Lorde

For most of my life, I asked myself a quiet question:

What’s wrong with me?

I didn’t say it out loud. I didn’t have to. It was stitched into how I moved through the world — hyperaware, self-correcting, and always just a little out of step. I knew how to “pass” in the right settings, but never without effort. Underneath it all, I was exhausted by the daily performance of normal.

Looking back, it’s clear where it started.

I grew up in a home marked by <a href="https://tinybuddha.com/bl…

Source https://tinybuddha.com/blog/brilliant-not-broken-a-powerful-reframe-for-neurodivergence/

“It is not our differences that divide us. It is our inability to recognize, accept, and celebrate those differences.” ~Audre Lorde

For most of my life, I asked myself a quiet question:

What’s wrong with me?

I didn’t say it out loud. I didn’t have to. It was stitched into how I moved through the world — hyperaware, self-correcting, and always just a little out of step. I knew how to “pass” in the right settings, but never without effort. Underneath it all, I was exhausted by the daily performance of normal.

Looking back, it’s clear where it started.

I grew up in a home marked by <a href="https://tinybuddha.com/bl…

Iron Metabolism in Osteoporosis

Source https://www.fightaging.org/archives/2025/09/iron-metabolism-in-osteoporosis/

Here find an interesting review of what is known of the role of iron metabolism in osteoporosis, the progressive loss of bone mineral density that occurs with age. Bone tissue is constantly remodeled throughout life, the bone extracellular matrix deposited by osteoblast cells and broken down by osteoclast cells. The loss of strength and increasing fragility of bone in older people arises because of a growing imbalance between osteoblast and osteoclast activity, favoring the osteoclasts. Thus there are many possible ways one could in principle intervene in this problem, most of these approaches not even touching on the underlying cau…

Source https://www.fightaging.org/archives/2025/09/iron-metabolism-in-osteoporosis/

Here find an interesting review of what is known of the role of iron metabolism in osteoporosis, the progressive loss of bone mineral density that occurs with age. Bone tissue is constantly remodeled throughout life, the bone extracellular matrix deposited by osteoblast cells and broken down by osteoclast cells. The loss of strength and increasing fragility of bone in older people arises because of a growing imbalance between osteoblast and osteoclast activity, favoring the osteoclasts. Thus there are many possible ways one could in principle intervene in this problem, most of these approaches not even touching on the underlying cau…

Open Thread: What’s Your Outdated Skill?

Source https://seniorplanet.org/articles-open-thread-outdated-skills/

What life skills do you have that are either extinct or on the way out?  Driving a manual transmission? Home sewing? Cursive?

The post Open Thread: What’s Your Outdated Skill? appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-open-thread-outdated-skills/

What life skills do you have that are either extinct or on the way out?  Driving a manual transmission? Home sewing? Cursive?

The post Open Thread: What’s Your Outdated Skill? appeared first on Senior Planet from AARP.

Get Social with Lifelong Learning

Source https://seniorplanet.org/articles-social-lifelong-learning/

Think you’re too old to go back to school? Think again! Here are just a few ways to expand your horizons, share your knowledge…and get social! 

The post Get Social with Lifelong Learning appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-social-lifelong-learning/

Think you’re too old to go back to school? Think again! Here are just a few ways to expand your horizons, share your knowledge…and get social! 

The post Get Social with Lifelong Learning appeared first on Senior Planet from AARP.

The Amish as a Point of Comparison for Long-Term Effects of Physical Exercise

Source https://www.fightaging.org/archives/2025/09/the-amish-as-a-point-of-comparison-for-long-term-effects-of-physical-exercise/

The epidemiological paper noted here shows that Amish life expectancy compares favorably with that of the surrounding population of the United States. While lifestyle choices for the Amish differ in many ways from the general population, their greater level of physical activity is an obvious point of focus. The dose-response curve for physical activity is fairly well characterized, and suggests that ever greater benefits to health and life expectancy continue to accrue up to twice or more the presently recommended 150 minutes per week of moderate to vigorous physical activity. The health of populations like the Amish and <a href="https://www.fightaging.org/archives/2016/11/hunter-gatherer-data-used-to-evaluate-the-…

Source https://www.fightaging.org/archives/2025/09/the-amish-as-a-point-of-comparison-for-long-term-effects-of-physical-exercise/

The epidemiological paper noted here shows that Amish life expectancy compares favorably with that of the surrounding population of the United States. While lifestyle choices for the Amish differ in many ways from the general population, their greater level of physical activity is an obvious point of focus. The dose-response curve for physical activity is fairly well characterized, and suggests that ever greater benefits to health and life expectancy continue to accrue up to twice or more the presently recommended 150 minutes per week of moderate to vigorous physical activity. The health of populations like the Amish and <a href="https://www.fightaging.org/archives/2016/11/hunter-gatherer-data-used-to-evaluate-the-…

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