It is never too late to start
Source https://seniorplanet.org/articles-social-lifelong-learning/
Think you’re too old to go back to school? Think again! Here are just a few ways to expand your horizons, share your knowledge…and get social!
The post Get Social with Lifelong Learning appeared first on Senior Planet from AARP.
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Source https://seniorplanet.org/articles-social-lifelong-learning/
Think you’re too old to go back to school? Think again! Here are just a few ways to expand your horizons, share your knowledge…and get social!
The post Get Social with Lifelong Learning appeared first on Senior Planet from AARP.
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The epidemiological paper noted here shows that Amish life expectancy compares favorably with that of the surrounding population of the United States. While lifestyle choices for the Amish differ in many ways from the general population, their greater level of physical activity is an obvious point of focus. The dose-response curve for physical activity is fairly well characterized, and suggests that ever greater benefits to health and life expectancy continue to accrue up to twice or more the presently recommended 150 minutes per week of moderate to vigorous physical activity. The health of populations like the Amish and <a href="https://www.fightaging.org/archives/2016/11/hunter-gatherer-data-used-to-evaluate-the-…
The epidemiological paper noted here shows that Amish life expectancy compares favorably with that of the surrounding population of the United States. While lifestyle choices for the Amish differ in many ways from the general population, their greater level of physical activity is an obvious point of focus. The dose-response curve for physical activity is fairly well characterized, and suggests that ever greater benefits to health and life expectancy continue to accrue up to twice or more the presently recommended 150 minutes per week of moderate to vigorous physical activity. The health of populations like the Amish and <a href="https://www.fightaging.org/archives/2016/11/hunter-gatherer-data-used-to-evaluate-the-…
The evidence of recent years derived from the study of the commensal microbes dwelling in the gastrointestinal tract makes it clear that the composition of this gut microbiome is influential on long term health, likely to a similar degree as exercise and diet. Further, the balance of microbial populations shifts with age in unfavorable ways. Inflammatory populations increase, contributing to the chronic inflammation of aging, while beneficial populations decrease, reducing the supply of metabolites necessary for normal tissue function.
While today’s open access paper is ostensibly focused on the connec…
The evidence of recent years derived from the study of the commensal microbes dwelling in the gastrointestinal tract makes it clear that the composition of this gut microbiome is influential on long term health, likely to a similar degree as exercise and diet. Further, the balance of microbial populations shifts with age in unfavorable ways. Inflammatory populations increase, contributing to the chronic inflammation of aging, while beneficial populations decrease, reducing the supply of metabolites necessary for normal tissue function.
While today’s open access paper is ostensibly focused on the connec…
In later life atherosclerotic plaques grow in blood vessel walls to narrow and weaken those vessels. When a plaque becomes unstable and ruptures, a downstream blockage can cause a heart attack or stroke. This and the slower harmful consequences of reduced blood flow via narrowed vessels makes atherosclerosis the largest cause of human mortality. Here, researchers provide evidence for long-lasting bacterial infection to be involved in the timing of plaque instability and rupture, particularly oral bacteria that have at some point entered the bloodstream. That said, at the point at which plaque is large enough to d…
In later life atherosclerotic plaques grow in blood vessel walls to narrow and weaken those vessels. When a plaque becomes unstable and ruptures, a downstream blockage can cause a heart attack or stroke. This and the slower harmful consequences of reduced blood flow via narrowed vessels makes atherosclerosis the largest cause of human mortality. Here, researchers provide evidence for long-lasting bacterial infection to be involved in the timing of plaque instability and rupture, particularly oral bacteria that have at some point entered the bloodstream. That said, at the point at which plaque is large enough to d…
Source https://www.americanspa.com/resource/gemini-evo-innovation-meets-elegance-italian-design-1
GEMINI EVO: innovation meets the elegance of Italian design.
Experience the sophistication of Italian craftsmanship with GEMINI EVO. Featuring a double-coated column structure and a painted wood base, it offers unmatched comfort and style. Customize with three colors – wengé, white, taupe – to fit any spa setting. Dive into a world where luxury meets practicality.
lbarrick
Fri, 12/06/2024 – 11:56
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Source https://www.americanspa.com/resource/gemini-evo-innovation-meets-elegance-italian-design-1
GEMINI EVO: innovation meets the elegance of Italian design.
Experience the sophistication of Italian craftsmanship with GEMINI EVO. Featuring a double-coated column structure and a painted wood base, it offers unmatched comfort and style. Customize with three colors – wengé, white, taupe – to fit any spa setting. Dive into a world where luxury meets practicality.
lbarrick
Fri, 12/06/2024 – 11:56
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Source https://tinybuddha.com/blog/the-truth-my-body-knew-before-my-mind-did/
Why did my stomach sink before a coffee date?
Why did I feel like I was going to vomit before a Zoom call?
Why did I freeze before taking a step toward the exact thing I said I wanted?
I used to think all of that meant something was wrong with me. Or maybe I was just anxious. Or overthinking. Or making it up. Pick a label.
But now I know better.
My body wasn…
Source https://tinybuddha.com/blog/the-truth-my-body-knew-before-my-mind-did/
Why did my stomach sink before a coffee date?
Why did I feel like I was going to vomit before a Zoom call?
Why did I freeze before taking a step toward the exact thing I said I wanted?
I used to think all of that meant something was wrong with me. Or maybe I was just anxious. Or overthinking. Or making it up. Pick a label.
But now I know better.
My body wasn…
Source https://tinybuddha.com/blog/the-2026-tiny-buddha-day-to-day-calendar-is-now-here/
Hi friends! I’m excited to share that the 2026 Tiny Buddha Day-to-Day Calendar is now available for purchase! And equally thrilling, I just found out my calendar was the number one bestseller in the Mind-Body-Spirit category for the last two years.
Uplifting and comforting, this calendar offers daily reflections from me, Tiny Buddha contributors, and other authors whose quotes have inspired and encouraged me.
Featuring colorful, patterned tear-off pages, the calendar is printed on FSC certified paper with soy-based ink. Topics include happiness, love, relationships, change, meaning, mindfulness, sel…
Source https://tinybuddha.com/blog/the-2026-tiny-buddha-day-to-day-calendar-is-now-here/
Hi friends! I’m excited to share that the 2026 Tiny Buddha Day-to-Day Calendar is now available for purchase! And equally thrilling, I just found out my calendar was the number one bestseller in the Mind-Body-Spirit category for the last two years.
Uplifting and comforting, this calendar offers daily reflections from me, Tiny Buddha contributors, and other authors whose quotes have inspired and encouraged me.
Featuring colorful, patterned tear-off pages, the calendar is printed on FSC certified paper with soy-based ink. Topics include happiness, love, relationships, change, meaning, mindfulness, sel…
Ferroptosis is a form of programmed cell death driven by iron accumulation and involving extensive lipid peroxidation as the kill mechanism. Senescent cells accumulate with age to cause tissue dysfunction and are resistant to programmed cell death. Most present approaches to the selective destruction of senescent cells as a form of therapy involve some form of sabotage of one or more programmed cell death resistance mechanisms. Here, researchers show that senescent cells both accumulate iron and resist ferroptosis, which suggests potential targets for novel forms of senolytic drug capable of selectively destroying senescent cells with minimal harm to normal cells.
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Ferroptosis is a form of programmed cell death driven by iron accumulation and involving extensive lipid peroxidation as the kill mechanism. Senescent cells accumulate with age to cause tissue dysfunction and are resistant to programmed cell death. Most present approaches to the selective destruction of senescent cells as a form of therapy involve some form of sabotage of one or more programmed cell death resistance mechanisms. Here, researchers show that senescent cells both accumulate iron and resist ferroptosis, which suggests potential targets for novel forms of senolytic drug capable of selectively destroying senescent cells with minimal harm to normal cells.
…
Source https://seniorplanet.org/articles-techspert-techbytes-episode-5/
In this TechBytes episode, the Techspert answers questions about emails, how to avoid roaming fees, internet speed, and more.
The post Ask The Techspert: TechBytes Episode 5 appeared first on Senior Planet from AARP.
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Source https://seniorplanet.org/articles-techspert-techbytes-episode-5/
In this TechBytes episode, the Techspert answers questions about emails, how to avoid roaming fees, internet speed, and more.
The post Ask The Techspert: TechBytes Episode 5 appeared first on Senior Planet from AARP.
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Many classes of therapy can be robustly manufactured with little risk of issues and do not need the full cost in time, effort, and funds of Good Manufacturing Practice (GMP) specified by the FDA in order for any given batch of the drug to be demonstrated to be safe. The most frequently used AAV vector serotypes, for example, are relatively safe in this way. One can manufacture a batch of an AAV drug with any one of the very experienced manufacturers in the same way one would for research in animals, and then run all of the quality assays needed to demonstrate that the batch is safe. This costs a lot less than full GMP but should produce essentially equivalent outcomes in safety.
<…
Many classes of therapy can be robustly manufactured with little risk of issues and do not need the full cost in time, effort, and funds of Good Manufacturing Practice (GMP) specified by the FDA in order for any given batch of the drug to be demonstrated to be safe. The most frequently used AAV vector serotypes, for example, are relatively safe in this way. One can manufacture a batch of an AAV drug with any one of the very experienced manufacturers in the same way one would for research in animals, and then run all of the quality assays needed to demonstrate that the batch is safe. This costs a lot less than full GMP but should produce essentially equivalent outcomes in safety.
<…