Bringing Affordable VEGF Gene Therapy to Medical Tourism Clinics

Source https://www.fightaging.org/archives/2025/09/bringing-affordable-vegf-gene-therapy-to-medical-tourism-clinics/

Many classes of therapy can be robustly manufactured with little risk of issues and do not need the full cost in time, effort, and funds of Good Manufacturing Practice (GMP) specified by the FDA in order for any given batch of the drug to be demonstrated to be safe. The most frequently used AAV vector serotypes, for example, are relatively safe in this way. One can manufacture a batch of an AAV drug with any one of the very experienced manufacturers in the same way one would for research in animals, and then run all of the quality assays needed to demonstrate that the batch is safe. This costs a lot less than full GMP but should produce essentially equivalent outcomes in safety.

<…

Source https://www.fightaging.org/archives/2025/09/bringing-affordable-vegf-gene-therapy-to-medical-tourism-clinics/

Many classes of therapy can be robustly manufactured with little risk of issues and do not need the full cost in time, effort, and funds of Good Manufacturing Practice (GMP) specified by the FDA in order for any given batch of the drug to be demonstrated to be safe. The most frequently used AAV vector serotypes, for example, are relatively safe in this way. One can manufacture a batch of an AAV drug with any one of the very experienced manufacturers in the same way one would for research in animals, and then run all of the quality assays needed to demonstrate that the batch is safe. This costs a lot less than full GMP but should produce essentially equivalent outcomes in safety.

<…

Could Curiosity Be the Best Medicine for Chronic Illness?

Source https://tinybuddha.com/blog/could-curiosity-be-the-best-medicine-for-chronic-illness/

Whether you think you can, or you think you can’t, you’re right.” ~Henry Ford

We’ve all been there: happily ticking off life’s checkboxes, certain we’ve cracked the code, until—bam!—life decides otherwise. Divorce papers, layoffs, grief, or unexpected illness—life’s curveballs don’t discriminate.

For me, it was a sudden mystery illness at sixteen. What should have been a simple infection changed the trajectory of my entire life. Doctors were at a loss, tests offered no answers, and I was left navigating an uncertain reality, desperately clinging to control as my lifeline.

One day I’m cheering at the Friday night footb…

Source https://tinybuddha.com/blog/could-curiosity-be-the-best-medicine-for-chronic-illness/

Whether you think you can, or you think you can’t, you’re right.” ~Henry Ford

We’ve all been there: happily ticking off life’s checkboxes, certain we’ve cracked the code, until—bam!—life decides otherwise. Divorce papers, layoffs, grief, or unexpected illness—life’s curveballs don’t discriminate.

For me, it was a sudden mystery illness at sixteen. What should have been a simple infection changed the trajectory of my entire life. Doctors were at a loss, tests offered no answers, and I was left navigating an uncertain reality, desperately clinging to control as my lifeline.

One day I’m cheering at the Friday night footb…

When Someone You Love Shuts the Door

Source https://tinybuddha.com/blog/when-someone-you-love-shuts-the-door/

“It is one thing to lose people you love. It is another to lose yourself. That is a greater loss.” ~Donna Goddard

We didn’t mean to fall into anything romantic. It started as friendship, collaboration, long voice notes about work, life, trauma, and healing. We helped each other solve problems. We gave each other pep talks before difficult meetings. He liked to say I had good instincts; I told him he had grit.

We shared vulnerabilities like flashlights in the dark—he told me about getting into fights, going to jail, losing jobs because he couldn’t keep his mouth shut. I shared about growing up in a home with yelling, hitting, and silence, and how I used to chase validation in relationships just to feel seen. Somewhere in there, something sparked…

Source https://tinybuddha.com/blog/when-someone-you-love-shuts-the-door/

“It is one thing to lose people you love. It is another to lose yourself. That is a greater loss.” ~Donna Goddard

We didn’t mean to fall into anything romantic. It started as friendship, collaboration, long voice notes about work, life, trauma, and healing. We helped each other solve problems. We gave each other pep talks before difficult meetings. He liked to say I had good instincts; I told him he had grit.

We shared vulnerabilities like flashlights in the dark—he told me about getting into fights, going to jail, losing jobs because he couldn’t keep his mouth shut. I shared about growing up in a home with yelling, hitting, and silence, and how I used to chase validation in relationships just to feel seen. Somewhere in there, something sparked…

Tech-savvy baby boomers will turn 80 soon – what’s it mean?

Source https://www.ageinplacetech.com/blog/tech-savvy-baby-boomers-will-turn-80-soon-what-s-it-mean

Baby boomer aging – it’s a big tech opportunity. Today there are 76 million US baby boomers, those born between 1946 and 1964.  They represent 21 percent of the US population.   73% of all wealth in the United States is concentrated among those over age 55, most of whom are baby boomers.   As the oldest of the baby boomers begin turning 80 in January of 2026,</a…

Source https://www.ageinplacetech.com/blog/tech-savvy-baby-boomers-will-turn-80-soon-what-s-it-mean

Baby boomer aging – it’s a big tech opportunity. Today there are 76 million US baby boomers, those born between 1946 and 1964.  They represent 21 percent of the US population.   73% of all wealth in the United States is concentrated among those over age 55, most of whom are baby boomers.   As the oldest of the baby boomers begin turning 80 in January of 2026,</a…

Dr. Calvin Mackie gives New Orleans STEM education

Source https://seniorplanet.org/dr-calvin-mackie-gives-new-orleans-stem-education/

Dr. Calvin Mackie started with encouraging his nine-year-old son’s love for science in a New Orleans garage – and launched STEM-NOLA, a movement that has reached over 200,000 children.

The post Dr. Calvin Mackie gives New Orleans STEM education appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/dr-calvin-mackie-gives-new-orleans-stem-education/

Dr. Calvin Mackie started with encouraging his nine-year-old son’s love for science in a New Orleans garage – and launched STEM-NOLA, a movement that has reached over 200,000 children.

The post Dr. Calvin Mackie gives New Orleans STEM education appeared first on Senior Planet from AARP.

I am richer than you think.

Source https://www.theminimalists.com/richer/

The Minimalists discuss what it means to live a rich life.

What is your version of a rich life? Let us know in the YouTube comments.

The post I am richer than you think. appeared first on The Minimalists.

Source https://www.theminimalists.com/richer/

The Minimalists discuss what it means to live a rich life.

What is your version of a rich life? Let us know in the YouTube comments.

The post I am richer than you think. appeared first on The Minimalists.

Senior Planet Book Club: Poll Results!

Source https://seniorplanet.org/articles-senior-planet-book-club-poll-results-oct-nov-2025/

The results are in, and we have our book selections for October and November!

The post Senior Planet Book Club: Poll Results! appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-senior-planet-book-club-poll-results-oct-nov-2025/

The results are in, and we have our book selections for October and November!

The post Senior Planet Book Club: Poll Results! appeared first on Senior Planet from AARP.

Endothelin B Receptor Inhibition Improves Axon Regrowth Following Injury

Source https://www.fightaging.org/archives/2025/09/endothelin-b-receptor-inhibition-improves-axon-regrowth-following-injury/

The peripheral nervous system is capable of regeneration, albeit not as much as desired. Lasting loss of function following injury is certainly possible, particularly following injury to larger nerves. The research community has long been interested in finding ways to improve this situation, some of which might be applicable to the much less regenerative central nervous system as well. Peripheral nerves are made up of bundled axons, long connections between neurons that pass signals back and forth. It is the regeneration of these axons that is the primary concern. Peripheral nervous system axons can be as much as several feet long, but even these are capable of regeneration and regrowth – at least until old age dismantles this ability along with ma…

Source https://www.fightaging.org/archives/2025/09/endothelin-b-receptor-inhibition-improves-axon-regrowth-following-injury/

The peripheral nervous system is capable of regeneration, albeit not as much as desired. Lasting loss of function following injury is certainly possible, particularly following injury to larger nerves. The research community has long been interested in finding ways to improve this situation, some of which might be applicable to the much less regenerative central nervous system as well. Peripheral nerves are made up of bundled axons, long connections between neurons that pass signals back and forth. It is the regeneration of these axons that is the primary concern. Peripheral nervous system axons can be as much as several feet long, but even these are capable of regeneration and regrowth – at least until old age dismantles this ability along with ma…

Are You Ready for the New Phones?

Source https://seniorplanet.org/articles-new-phone/

This month, the Tech Hub reveals the seven important criteria to consider when buying a new phone. 

The post Are You Ready for the New Phones? appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-new-phone/

This month, the Tech Hub reveals the seven important criteria to consider when buying a new phone. 

The post Are You Ready for the New Phones? appeared first on Senior Planet from AARP.

The Unexpected Way Jiu-Jitsu Brought Me Back to Myself

Source https://tinybuddha.com/blog/the-unexpected-way-jiu-jitsu-brought-me-back-to-myself/

“You may encounter many defeats, but you must not be defeated. In fact, it may be necessary to encounter the defeats, so you can know who you are.” ~Maya Angelou

There was a time in my life when everything felt heavy, like I was constantly carrying around a weight that no one else could see.

I wasn’t in a crisis, exactly. I was functioning, showing up, doing what needed to be done. But inside, I was struggling to stay afloat—trapped in my own head, questioning my worth, and unsure how to move forward.

One evening, I walked into a Brazilian Jiu-Jitsu class for the first time. I had no idea what I was doing. I didn’t know the rules, the language, or even how to tie the belt on…

Source https://tinybuddha.com/blog/the-unexpected-way-jiu-jitsu-brought-me-back-to-myself/

“You may encounter many defeats, but you must not be defeated. In fact, it may be necessary to encounter the defeats, so you can know who you are.” ~Maya Angelou

There was a time in my life when everything felt heavy, like I was constantly carrying around a weight that no one else could see.

I wasn’t in a crisis, exactly. I was functioning, showing up, doing what needed to be done. But inside, I was struggling to stay afloat—trapped in my own head, questioning my worth, and unsure how to move forward.

One evening, I walked into a Brazilian Jiu-Jitsu class for the first time. I had no idea what I was doing. I didn’t know the rules, the language, or even how to tie the belt on…

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