Source https://www.theminimalists.com/prenup/
Joshua Fields Millburn discusses whether minimalists should get a prenup.
How do you feel about prenups? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post Should I Get a Prenuptial Agreement? appeared first on The Minimalists.
…
Source https://www.theminimalists.com/prenup/
Joshua Fields Millburn discusses whether minimalists should get a prenup.
How do you feel about prenups? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post Should I Get a Prenuptial Agreement? appeared first on The Minimalists.
…
Source https://tinybuddha.com/blog/6-simple-things-i-do-when-life-feels-completely-overwhelming/

“You can’t calm the storm, so stop trying. What you can do is calm yourself. The storm will pass.” ~Timber Hawkeye
Overwhelm doesn’t always knock politely. Sometimes it crashes into my day like an unexpected storm—suddenly I can’t think straight, and everything feels urgent, impossible, and too loud. One minute I’m fine, the next I’m spiraling in my head, convinced I’m falling behind on everything and failing everyone.
If you’ve ever sat frozen in your car in the grocery store parking lot, staring blankly at a to-do list that now feels like a personal attack, you’re not alone.
Here are six things I turn to when I feel completely overwhelmed—none of them fix everything, but …
Source https://tinybuddha.com/blog/6-simple-things-i-do-when-life-feels-completely-overwhelming/

“You can’t calm the storm, so stop trying. What you can do is calm yourself. The storm will pass.” ~Timber Hawkeye
Overwhelm doesn’t always knock politely. Sometimes it crashes into my day like an unexpected storm—suddenly I can’t think straight, and everything feels urgent, impossible, and too loud. One minute I’m fine, the next I’m spiraling in my head, convinced I’m falling behind on everything and failing everyone.
If you’ve ever sat frozen in your car in the grocery store parking lot, staring blankly at a to-do list that now feels like a personal attack, you’re not alone.
Here are six things I turn to when I feel completely overwhelmed—none of them fix everything, but …
Source https://www.fightaging.org/archives/2025/09/repurposing-the-normal-clearance-of-dead-cells-to-target-unwanted-live-cells/
Researchers here describe an interesting approach to redirecting the immune system to destroy unwanted cells. The membranes of dead cells are distinctively marked and immune cells contain machinery to recognize those marks. This is an important part of the way in which immune cells are directed to engulf and destroy dead cells and cell debris, helping to keep tissue functional. If immune cells are equipped instead with an altered, engineered sensor mechanism, then in principle their well-established behavior of engulfing and destroying dead cells could be repurposed to attack any specific target live cell population. This has applications to many conditions of aging, as researchers have identified many errant, malfunctioning cell populations that contribute to age-related disease and dysfunction. Efficient and safe ways to remove these cells will provide the basis fo…
Source https://www.fightaging.org/archives/2025/09/repurposing-the-normal-clearance-of-dead-cells-to-target-unwanted-live-cells/
Researchers here describe an interesting approach to redirecting the immune system to destroy unwanted cells. The membranes of dead cells are distinctively marked and immune cells contain machinery to recognize those marks. This is an important part of the way in which immune cells are directed to engulf and destroy dead cells and cell debris, helping to keep tissue functional. If immune cells are equipped instead with an altered, engineered sensor mechanism, then in principle their well-established behavior of engulfing and destroying dead cells could be repurposed to attack any specific target live cell population. This has applications to many conditions of aging, as researchers have identified many errant, malfunctioning cell populations that contribute to age-related disease and dysfunction. Efficient and safe ways to remove these cells will provide the basis fo…
Source https://www.fightaging.org/archives/2025/09/electrical-stimulation-can-induce-macrophages-into-the-pro-regenerative-m2-phenotype/
Why do some applications of electric fields appear to enhance regeneration from injury? The study of the effects of electromagnetism on cell behavior lags far behind the study of biochemistry, the effects of proteins and small molecules. Here, researchers provide evidence for electrical stimulation to be able to shift macrophage cells into a more pro-regenerative state. Macrophages are innate immune cells resident in tissue that conduct a wide range of tasks relating to defense against pathogens, destruction of harmful cells, and …
Source https://www.fightaging.org/archives/2025/09/electrical-stimulation-can-induce-macrophages-into-the-pro-regenerative-m2-phenotype/
Why do some applications of electric fields appear to enhance regeneration from injury? The study of the effects of electromagnetism on cell behavior lags far behind the study of biochemistry, the effects of proteins and small molecules. Here, researchers provide evidence for electrical stimulation to be able to shift macrophage cells into a more pro-regenerative state. Macrophages are innate immune cells resident in tissue that conduct a wide range of tasks relating to defense against pathogens, destruction of harmful cells, and …
Source https://tinybuddha.com/blog/how-understanding-complex-trauma-deepened-my-ability-to-love-myself/

“Being present for your own life is the most radical act of self-compassion you can offer yourself.” ~Sylvia Boorstein
In 2004, I experienced a powerful breakthrough in understanding what it meant to love myself. I could finally understand that self-love is about the relationship that you have with yourself, and that relationship is expressed in how you speak to yourself, treat yourself, and see yourself. I also understood that self-love is about knowing yourself and paying attention to what you need.
These discoveries, and others, changed my life and led me into a new direction. But as the years went by, I began to feel exhausted…
Source https://tinybuddha.com/blog/how-understanding-complex-trauma-deepened-my-ability-to-love-myself/

“Being present for your own life is the most radical act of self-compassion you can offer yourself.” ~Sylvia Boorstein
In 2004, I experienced a powerful breakthrough in understanding what it meant to love myself. I could finally understand that self-love is about the relationship that you have with yourself, and that relationship is expressed in how you speak to yourself, treat yourself, and see yourself. I also understood that self-love is about knowing yourself and paying attention to what you need.
These discoveries, and others, changed my life and led me into a new direction. But as the years went by, I began to feel exhausted…
Source https://seniorplanet.org/articles-es-aniversario-60-de-medicare-y-actualizacion/
Entre recortes de personal e inquietudes acerca de la reducción de beneficios, hay mucho que reflexionar a medida que se acerca el aniversario 60 de Medicare.
The post Aniversario 60 de Medicare y actualización appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-es-aniversario-60-de-medicare-y-actualizacion/
Entre recortes de personal e inquietudes acerca de la reducción de beneficios, hay mucho que reflexionar a medida que se acerca el aniversario 60 de Medicare.
The post Aniversario 60 de Medicare y actualización appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2025/09/treating-neurodegeneration-with-monocytes-and-macrophages-derived-from-induced-pluripotent-stem-cells/
Innate immune cells, particularly monocytes and macrophages, are important to tissue function throughout the body. Like all cell populations, they become dysfunction in various ways with advancing age. A particular issue is that these cells become more inflammatory. These cells are not present in the brain to any great degree; the brain has its own population of analogous cells called microglia. Thus it is interesting to see that delivering functional, youthful monocytes and macrophages into circulation can improve function in the aging brain. There are likely many indirect mechanisms at work beyond the question of the chronic inflammation of a…
Source https://www.fightaging.org/archives/2025/09/treating-neurodegeneration-with-monocytes-and-macrophages-derived-from-induced-pluripotent-stem-cells/
Innate immune cells, particularly monocytes and macrophages, are important to tissue function throughout the body. Like all cell populations, they become dysfunction in various ways with advancing age. A particular issue is that these cells become more inflammatory. These cells are not present in the brain to any great degree; the brain has its own population of analogous cells called microglia. Thus it is interesting to see that delivering functional, youthful monocytes and macrophages into circulation can improve function in the aging brain. There are likely many indirect mechanisms at work beyond the question of the chronic inflammation of a…
Source https://www.fightaging.org/archives/2025/09/towards-better-approaches-to-systemic-delivery-of-gene-therapies/
The biggest challenge facing the deployment of gene therapies for the treatment of aging and age-related disease is that delivery systems are lacking. There is no well established way to safely and robustly deliver a payload of sufficient size to most organs (or all organs) without multiple direct injections, an approach that bears an unacceptable risk when deployed across very large numbers of relatively healthy people. When delivering a gene therapy via intravenous injection, the bloodstream carries most of the payload to the liver and lungs, and this limits the amount of drug that can be introduced to any given other organ because delivery systems are toxic at higher doses. The amount that ends up in the liver dramatically limits what can be done.
A connected issue is that the options for selective expression of a <a href="https://en.wikipedia.org/w…
Source https://www.fightaging.org/archives/2025/09/towards-better-approaches-to-systemic-delivery-of-gene-therapies/
The biggest challenge facing the deployment of gene therapies for the treatment of aging and age-related disease is that delivery systems are lacking. There is no well established way to safely and robustly deliver a payload of sufficient size to most organs (or all organs) without multiple direct injections, an approach that bears an unacceptable risk when deployed across very large numbers of relatively healthy people. When delivering a gene therapy via intravenous injection, the bloodstream carries most of the payload to the liver and lungs, and this limits the amount of drug that can be introduced to any given other organ because delivery systems are toxic at higher doses. The amount that ends up in the liver dramatically limits what can be done.
A connected issue is that the options for selective expression of a <a href="https://en.wikipedia.org/w…