Author: Tom

Source https://www.fightaging.org/archives/2025/09/treating-neurodegeneration-with-monocytes-and-macrophages-derived-from-induced-pluripotent-stem-cells/

Innate immune cells, particularly monocytes and macrophages, are important to tissue function throughout the body. Like all cell populations, they become dysfunction in various ways with advancing age. A particular issue is that these cells become more inflammatory. These cells are not present in the brain to any great degree; the brain has its own population of analogous cells called microglia. Thus it is interesting to see that delivering functional, youthful monocytes and macrophages into circulation can improve function in the aging brain. There are likely many indirect mechanisms at work beyond the question of the chronic inflammation of a…

Source https://www.fightaging.org/archives/2025/09/towards-better-approaches-to-systemic-delivery-of-gene-therapies/

The biggest challenge facing the deployment of gene therapies for the treatment of aging and age-related disease is that delivery systems are lacking. There is no well established way to safely and robustly deliver a payload of sufficient size to most organs (or all organs) without multiple direct injections, an approach that bears an unacceptable risk when deployed across very large numbers of relatively healthy people. When delivering a gene therapy via intravenous injection, the bloodstream carries most of the payload to the liver and lungs, and this limits the amount of drug that can be introduced to any given other organ because delivery systems are toxic at higher doses. The amount that ends up in the liver dramatically limits what can be done.

A connected issue is that the options for selective expression of a <a href="https://en.wikipedia.org/w…

Source https://seniorplanet.org/articles-es-usar-la-ia-para-planificar-su-viaje/

¿Está pensando en viajar pronto? Aprenda a utilizar la IA para hacer la planificación de viajes más fácil, rápida y divertida.

The post Pregúntele al Techspert: Cómo usar la IA para planificar su próximo viaje appeared first on Senior Planet from AARP.

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Source https://seniorplanet.org/articles-the-abcs-of-rmds/

Tax deferred retirement accounts aren’t tax free. Learn about changes in the laws covering mandatory – and taxable – Required Minimum Distributions.

The post The ABC’s of RMD’s appeared first on Senior Planet from AARP.

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Source https://www.theminimalists.com/p504/

In this solo episode, Joshua talks about disagreeing about the little things at home, his new rule for online shopping, a few stupid things he’s purchased that he’ll never buy again, and much more.

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Source https://seniorplanet.org/articles-es-bienestar-y-cambio-con-lorena-jiron/

¡Bienvenidos! Están invitados a unirse a esta serie de cuatro sesiones para explorar el autocuidado y el empoderamiento después de los 60.

The post Bienestar y Cambio con Lorena Jirón appeared first on Senior Planet from AARP.

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Source https://www.fightaging.org/archives/2025/09/fight-aging-newsletter-september-8th-2025/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
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Source https://seniorplanet.org/articles-open-thread-the-end-of-aol/

Share your first brush with AOL’s dial up service while those CD discs join VCR players, Blackberries and pagers on the ash heap of tech history – unless you still have them, of course!

The post Open Thread: The End of a <em>*Bop TWEE!*</em> Era appeared first on Senior Planet from AARP.

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Source https://www.fightaging.org/archives/2025/09/towards-a-better-understanding-of-lysosomal-stress/

Lysosomes are recycling systems inside a cell, organelles that contain enzymes capable of breaking down proteins and cell structures into raw materials for reuse. The cell maintenance processes of autophagy are responsible for identifying proteins and structures that should be recycled and deliver them to a lysosome. Lysosomal dysfunction is a feature of aging in long-lived cells, as the lysosomes become filled with persistent metabolic waste that they struggle to break down. Enlargement of lysosomes is observed in this situation, and researchers here explore this phenomenon with an eye to find ways to manipulate lysosomal…

Source https://www.fightaging.org/archives/2025/09/old-age-and-low-fitness-independently-correlate-with-risk-of-arrhythmia/

Arrythmia can be a precursor of later, more severe heart issues, indicative of a level of dysfunction in heart tissue arising due to aging or other causes. It can also result from electrolyte imbalances that in turn arise from lifestyle choices. Arrythmia is generally taken as a point of concern by physicians where it occurs in older patients. Here, researchers show that a low level of fitness is independently a risk factor in the development of arrythmia, distinctly from old age. There are many other well-known reasons to maintain fitness into later life, but perhaps this finding will motivate an additional segment of the population.

New research has revealed that older age and low aerobic fitness levels are strong and independent risk factors for a high burde…