Source https://www.fightaging.org/archives/2025/09/old-age-and-low-fitness-independently-correlate-with-risk-of-arrhythmia/
Arrythmia can be a precursor of later, more severe heart issues, indicative of a level of dysfunction in heart tissue arising due to aging or other causes. It can also result from electrolyte imbalances that in turn arise from lifestyle choices. Arrythmia is generally taken as a point of concern by physicians where it occurs in older patients. Here, researchers show that a low level of fitness is independently a risk factor in the development of arrythmia, distinctly from old age. There are many other well-known reasons to maintain fitness into later life, but perhaps this finding will motivate an additional segment of the population.
New research has revealed that older age and low aerobic fitness levels are strong and independent risk factors for a high burde…
Source https://www.fightaging.org/archives/2025/09/old-age-and-low-fitness-independently-correlate-with-risk-of-arrhythmia/
Arrythmia can be a precursor of later, more severe heart issues, indicative of a level of dysfunction in heart tissue arising due to aging or other causes. It can also result from electrolyte imbalances that in turn arise from lifestyle choices. Arrythmia is generally taken as a point of concern by physicians where it occurs in older patients. Here, researchers show that a low level of fitness is independently a risk factor in the development of arrythmia, distinctly from old age. There are many other well-known reasons to maintain fitness into later life, but perhaps this finding will motivate an additional segment of the population.
New research has revealed that older age and low aerobic fitness levels are strong and independent risk factors for a high burde…
Source https://www.fightaging.org/archives/2025/09/dysfunction-in-cerebrovascular-blood-flow-in-alzheimers-disease/
To what degree is the neurodegeneration of Alzheimer’s disease driven by reduced blood flow to brain tissue? This is as compared to the contributions of the well-studied aggregation of amyloid-β and tau proteins, or the neuroinflammation driven by senescent cells, persistent viral infection, and various forms of molecular damage in and around cells. One of the challenges inherent in investigations of aging and age-related disease is that it is very hard to determine the relativ…
Source https://www.fightaging.org/archives/2025/09/dysfunction-in-cerebrovascular-blood-flow-in-alzheimers-disease/
To what degree is the neurodegeneration of Alzheimer’s disease driven by reduced blood flow to brain tissue? This is as compared to the contributions of the well-studied aggregation of amyloid-β and tau proteins, or the neuroinflammation driven by senescent cells, persistent viral infection, and various forms of molecular damage in and around cells. One of the challenges inherent in investigations of aging and age-related disease is that it is very hard to determine the relativ…
Source https://www.fightaging.org/archives/2025/09/interactions-between-oral-and-gut-microbiomes-in-the-context-of-age-related-disease/
The gut microbiome has received a great deal of attention in recent years, spurred by the ability to accurately and cheaply assess the composition of the gut microbiome, specific species and their proportions, via 16S rRNA sequencing. Researchers have demonstrated that the composition of the gut microbiome shifts with age to favor species that generate chronic inflammation at the expense of species producing beneficial metabolites needed for tissue function. Researchers are also turning th…
Source https://www.fightaging.org/archives/2025/09/interactions-between-oral-and-gut-microbiomes-in-the-context-of-age-related-disease/
The gut microbiome has received a great deal of attention in recent years, spurred by the ability to accurately and cheaply assess the composition of the gut microbiome, specific species and their proportions, via 16S rRNA sequencing. Researchers have demonstrated that the composition of the gut microbiome shifts with age to favor species that generate chronic inflammation at the expense of species producing beneficial metabolites needed for tissue function. Researchers are also turning th…
Source https://www.fightaging.org/archives/2025/09/herpes-zoster-vaccination-correlates-with-lower-risk-of-stroke-and-heart-attack/
Vaccinations have been shown to produce a phenomenon called trained immunity. Effects include (a) increased responsiveness to pathogens other than the one vaccinated against, and (b) reduced chronic inflammation in later life. Trained immunity is well studied for the former phenomenon, but less well studied for the latter; questions remain as to whether different forms of vaccination for the same pathogen have different effects, for example. Correlations between later life vaccination and reduced risk of age-related disease and dysfunction have been observed, but it remains an open question as to whether this reflects trained immunity effects versus late life vaccination, a voluntary process, selecting for …
Source https://www.fightaging.org/archives/2025/09/herpes-zoster-vaccination-correlates-with-lower-risk-of-stroke-and-heart-attack/
Vaccinations have been shown to produce a phenomenon called trained immunity. Effects include (a) increased responsiveness to pathogens other than the one vaccinated against, and (b) reduced chronic inflammation in later life. Trained immunity is well studied for the former phenomenon, but less well studied for the latter; questions remain as to whether different forms of vaccination for the same pathogen have different effects, for example. Correlations between later life vaccination and reduced risk of age-related disease and dysfunction have been observed, but it remains an open question as to whether this reflects trained immunity effects versus late life vaccination, a voluntary process, selecting for …
Source https://www.nerdfitness.com/blog/3-times-motivation-dips/
I’m trying something a little different today.
Over the past 15 years of working with clients, I’ve learned that success in fitness isn’t just about knowing what to do… it’s about having strategies for when things inevitably get tough.
Where do habits usually break down? Why does motivation fizzle out? And what can we actually do about it?
…
Source https://www.nerdfitness.com/blog/3-times-motivation-dips/
I’m trying something a little different today.
Over the past 15 years of working with clients, I’ve learned that success in fitness isn’t just about knowing what to do… it’s about having strategies for when things inevitably get tough.
Where do habits usually break down? Why does motivation fizzle out? And what can we actually do about it?
…
Source https://www.fightaging.org/archives/2025/09/variant-sequences-that-reduce-il-6-signaling-correlate-with-a-lower-risk-of-cardiovascular-disease/
Researchers here analyze human genetic variants in the IL-6 gene to show that reduced IL-6 activity correlates with a lower risk of cardiovascular disease. Circulating IL-6 is generally thought of as a pro-inflammatory signal, and it is a target for the development of therapies. Chronic inflammation in later life is an important contribution to dysfunction and disease, and better control over this maladaptive inflammatory reaction to the cell and tissue damage that characterizes aging is a desirable goal.
Human genetics supports a causal involvement of IL-6 signaling in atherosclerotic cardiovascular disease, prompting the clinical development of anti-IL-6 therapies. Genetic evidence has historically focused…
Source https://www.fightaging.org/archives/2025/09/variant-sequences-that-reduce-il-6-signaling-correlate-with-a-lower-risk-of-cardiovascular-disease/
Researchers here analyze human genetic variants in the IL-6 gene to show that reduced IL-6 activity correlates with a lower risk of cardiovascular disease. Circulating IL-6 is generally thought of as a pro-inflammatory signal, and it is a target for the development of therapies. Chronic inflammation in later life is an important contribution to dysfunction and disease, and better control over this maladaptive inflammatory reaction to the cell and tissue damage that characterizes aging is a desirable goal.
Human genetics supports a causal involvement of IL-6 signaling in atherosclerotic cardiovascular disease, prompting the clinical development of anti-IL-6 therapies. Genetic evidence has historically focused…
Source https://www.fightaging.org/archives/2025/09/evidence-for-accelerated-epigenetic-aging-to-correlate-with-loss-of-cognitive-function/
Researchers have developed many aging clocks in recent years. Machine learning techniques are applied to large sets of biological data assessed at various ages in order to identify algorithms that predict chronological age, mortality risk, disease risk, or other measures of interest. If an individual has a predicted age higher than chronological age, this is known as accelerated biological age. A major challenge facing the use of clocks at present is that most clocks are inscrutable, in the sense that little to nothing is known of how the individual values making up the clock algorithm are linked to specific underlying mechanisms of aging or specific outcomes of age-related dysfunction and disease.
One path to making this situation better is …
Source https://www.fightaging.org/archives/2025/09/evidence-for-accelerated-epigenetic-aging-to-correlate-with-loss-of-cognitive-function/
Researchers have developed many aging clocks in recent years. Machine learning techniques are applied to large sets of biological data assessed at various ages in order to identify algorithms that predict chronological age, mortality risk, disease risk, or other measures of interest. If an individual has a predicted age higher than chronological age, this is known as accelerated biological age. A major challenge facing the use of clocks at present is that most clocks are inscrutable, in the sense that little to nothing is known of how the individual values making up the clock algorithm are linked to specific underlying mechanisms of aging or specific outcomes of age-related dysfunction and disease.
One path to making this situation better is …
Source https://tinybuddha.com/blog/the-beautiful-losses-of-a-childhood-moved-to-the-philippines/
“The only way to make sense out of change is to plunge into it, move with it, and join the dance.” ~Alan Watts
I must admit, dear reader, that I wasn’t always a fan of change—not even a little. I wouldn’t say I entered this world naturally inclined toward new or unfamiliar things.
Like many children, I found comfort in routine—the joy that comes from ordinary moments repeating themselves. Whether we realize it or not, repetition builds a mental framework that quietly defines our comfort zones.
Maybe that’s where identity begins, slowly shaped over time. And perhaps that’s why, while others struggle to recall the…
Source https://tinybuddha.com/blog/the-beautiful-losses-of-a-childhood-moved-to-the-philippines/
“The only way to make sense out of change is to plunge into it, move with it, and join the dance.” ~Alan Watts
I must admit, dear reader, that I wasn’t always a fan of change—not even a little. I wouldn’t say I entered this world naturally inclined toward new or unfamiliar things.
Like many children, I found comfort in routine—the joy that comes from ordinary moments repeating themselves. Whether we realize it or not, repetition builds a mental framework that quietly defines our comfort zones.
Maybe that’s where identity begins, slowly shaped over time. And perhaps that’s why, while others struggle to recall the…
Source https://www.theminimalists.com/products/
The Minimalists speak with philosopher Peter Rollins about the inevitable dissatisfaction of buying stuff.
What’s the most unsatisfying purchase you’ve ever made? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post Products Promise Fulfillment but Give Us Dissatisfaction appeared first on The Minimalists.
…
Source https://www.theminimalists.com/products/
The Minimalists speak with philosopher Peter Rollins about the inevitable dissatisfaction of buying stuff.
What’s the most unsatisfying purchase you’ve ever made? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post Products Promise Fulfillment but Give Us Dissatisfaction appeared first on The Minimalists.
…