It is never too late to start
Source https://seniorplanet.org/articles-senior-planet-melissa-leo/
Oscar and Emmy winning actress Melissa Leo, 64, talks about playing a detective in the new drama, The Knife, pottery, and the New York stage.
The post Senior Planet Talks to…Melissa Leo appeared first on Senior Planet from AARP.
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Source https://seniorplanet.org/articles-senior-planet-melissa-leo/
Oscar and Emmy winning actress Melissa Leo, 64, talks about playing a detective in the new drama, The Knife, pottery, and the New York stage.
The post Senior Planet Talks to…Melissa Leo appeared first on Senior Planet from AARP.
…
Source https://tinybuddha.com/blog/pay-what-you-can-for-21-days-of-laughs-and-light/
My electric toothbrush has seen it all.
I usually look in the mirror when I’m brushing my teeth, and for a while last fall, I often cried when I stared into my own eyes.
I did my best to hold it together in front of my sons—most of the time, anyway. But the mask often cracked when I met my own gaze. Deep sobs set to the gentle hum of my sonic. Life was just that overwhelming—with medical issues, a loved one’s shock diagnosis, and countless other challenges too numerous to list.
Then one day, after months of carrying more emotional weight than I had in decades, I decided to start looking for little ways to make myself smile again. And that toothbrush became a microphone.
First it was dramatic, cathartic songs like Fix …
Source https://tinybuddha.com/blog/pay-what-you-can-for-21-days-of-laughs-and-light/
My electric toothbrush has seen it all.
I usually look in the mirror when I’m brushing my teeth, and for a while last fall, I often cried when I stared into my own eyes.
I did my best to hold it together in front of my sons—most of the time, anyway. But the mask often cracked when I met my own gaze. Deep sobs set to the gentle hum of my sonic. Life was just that overwhelming—with medical issues, a loved one’s shock diagnosis, and countless other challenges too numerous to list.
Then one day, after months of carrying more emotional weight than I had in decades, I decided to start looking for little ways to make myself smile again. And that toothbrush became a microphone.
First it was dramatic, cathartic songs like Fix …
Source https://www.fightaging.org/archives/2025/08/r-loop-dna-provokes-chronic-inflammation-via-cgas-sting/
Stretches of nuclear DNA can adopt a broad range of transient structural forms, guided by the complex feedback loops of epigenetic marks, decorating molecules added to and removed from DNA. Epigenetics as a form of control over gene expression is all a matter of structure: which regions are packaged up and inaccessible, which are accessible. Other processes can also have their effects on local structure of the DNA, however. Some of the resulting structural forms can be problematic, and might be thought of as damage or dysfunction or an unwanted side-effect of those processes operating on DNA. This is all fairly well described by the scientific community, with an established nomenclature for different structural features.
In this context, an R-loop …
Source https://www.fightaging.org/archives/2025/08/r-loop-dna-provokes-chronic-inflammation-via-cgas-sting/
Stretches of nuclear DNA can adopt a broad range of transient structural forms, guided by the complex feedback loops of epigenetic marks, decorating molecules added to and removed from DNA. Epigenetics as a form of control over gene expression is all a matter of structure: which regions are packaged up and inaccessible, which are accessible. Other processes can also have their effects on local structure of the DNA, however. Some of the resulting structural forms can be problematic, and might be thought of as damage or dysfunction or an unwanted side-effect of those processes operating on DNA. This is all fairly well described by the scientific community, with an established nomenclature for different structural features.
In this context, an R-loop …
Urolithin A is one of a number of molecules regulated as supplements that is known to modestly improve mitochondrial function. A number of companies are working on deriving drugs from modified forms of urolithin A, while the research community is more focused on trying to understand how exactly it improves mitochondrial function. The effect size is not large, as is the case for better understood approaches to improve mitochondrial function in aged tissues, such as the various ways to increase NAD+ in mitochondria, and delivery of forms of mitochondrially targeted antioxidant. These various molecules tend to produce results …
Urolithin A is one of a number of molecules regulated as supplements that is known to modestly improve mitochondrial function. A number of companies are working on deriving drugs from modified forms of urolithin A, while the research community is more focused on trying to understand how exactly it improves mitochondrial function. The effect size is not large, as is the case for better understood approaches to improve mitochondrial function in aged tissues, such as the various ways to increase NAD+ in mitochondria, and delivery of forms of mitochondrially targeted antioxidant. These various molecules tend to produce results …
Source https://www.fightaging.org/archives/2025/08/reviewing-the-role-of-inflammasomes-in-aging/
Constant, unresolved inflammatory signaling is a feature of aging. It occurs in absence of the usual provocations of infection and injury, and is disruptive to tissue structure and function. Normal, short-term inflammation is useful and necessary, but long-term inflammation is harmful. It changes cell behavior for the worse, causes the normal processes of tissue maintenance to run awry, degrades the effectiveness of the immune system, encourages growth of cancers, and contributes to the onset and progression of all of the common fatal diseases of aging.
Much of this unwanted inflammation of aging is caused by the reaction of inflammasomes to the molecular damage present in an aged cell. Inflammasomes are protein complexes that evolved to react to the presence of molecules characteristic of infect…
Source https://www.fightaging.org/archives/2025/08/reviewing-the-role-of-inflammasomes-in-aging/
Constant, unresolved inflammatory signaling is a feature of aging. It occurs in absence of the usual provocations of infection and injury, and is disruptive to tissue structure and function. Normal, short-term inflammation is useful and necessary, but long-term inflammation is harmful. It changes cell behavior for the worse, causes the normal processes of tissue maintenance to run awry, degrades the effectiveness of the immune system, encourages growth of cancers, and contributes to the onset and progression of all of the common fatal diseases of aging.
Much of this unwanted inflammation of aging is caused by the reaction of inflammasomes to the molecular damage present in an aged cell. Inflammasomes are protein complexes that evolved to react to the presence of molecules characteristic of infect…
Source https://tinybuddha.com/blog/i-spent-years-chasing-love-until-i-finally-chose-myself/
“The only people who get upset when you set boundaries are the ones who benefited from you having none.” ~Unknown
For most of my life, I lived with a quiet ache, a longing I couldn’t quite name but always felt. I wanted to be chosen. Not just liked or tolerated, but fully seen, wanted, and loved.
That longing shaped so many of my choices. I over-gave in relationships, staying in situations far longer than I should have, and shrank myself to be accepted.
I didn’t know it at the time, but I was trying to fill an emptiness that had started years before, an emptiness born in silence and absence, in words left unsaid and emotions left unacknowledged.
You see, I grew up …
Source https://tinybuddha.com/blog/i-spent-years-chasing-love-until-i-finally-chose-myself/
“The only people who get upset when you set boundaries are the ones who benefited from you having none.” ~Unknown
For most of my life, I lived with a quiet ache, a longing I couldn’t quite name but always felt. I wanted to be chosen. Not just liked or tolerated, but fully seen, wanted, and loved.
That longing shaped so many of my choices. I over-gave in relationships, staying in situations far longer than I should have, and shrank myself to be accepted.
I didn’t know it at the time, but I was trying to fill an emptiness that had started years before, an emptiness born in silence and absence, in words left unsaid and emotions left unacknowledged.
You see, I grew up …
The hundreds of mitochondria present in every cell are responsible for generating the chemical energy store molecule adenosine triphosphate to power cell processes. Dysfunction in the mitochondrial population is characteristic of aging and thought to be a meaningful contribution to loss of tissue function. This dysfunction arises in part because the quality control mechanisms that cull damaged mitochondria become less effective. When functioning correctly, the processes of mitophagy identify and flag damaged mitochondria, which are then conducted to a lysosome, engulfed, and broken down. The remaining mitochondria replicate to make up their numbers. M…
The hundreds of mitochondria present in every cell are responsible for generating the chemical energy store molecule adenosine triphosphate to power cell processes. Dysfunction in the mitochondrial population is characteristic of aging and thought to be a meaningful contribution to loss of tissue function. This dysfunction arises in part because the quality control mechanisms that cull damaged mitochondria become less effective. When functioning correctly, the processes of mitophagy identify and flag damaged mitochondria, which are then conducted to a lysosome, engulfed, and broken down. The remaining mitochondria replicate to make up their numbers. M…
There is some debate over whether GLP-1 receptor agonist drugs such as semaglutide can affect mechanisms relevant to aging independently of weight loss. GLP-1 receptors are present in many organs, including the brain, so it is not unreasonable to think that other outcomes may result from GLP-1 receptor agonism over and above reduced appetite and calorie intake. But do those outcomes slow aging to a meaningful degree in comparison to the effects of weight loss? That is where we should be appropriately skeptical.
Compelling mechanistic and epidemiological data indicates that excess visceral fat tissue accelerates aging,…
There is some debate over whether GLP-1 receptor agonist drugs such as semaglutide can affect mechanisms relevant to aging independently of weight loss. GLP-1 receptors are present in many organs, including the brain, so it is not unreasonable to think that other outcomes may result from GLP-1 receptor agonism over and above reduced appetite and calorie intake. But do those outcomes slow aging to a meaningful degree in comparison to the effects of weight loss? That is where we should be appropriately skeptical.
Compelling mechanistic and epidemiological data indicates that excess visceral fat tissue accelerates aging,…
Source https://www.ageinplacetech.com/blog/ai-and-older-adults-surprise-surprise-it-accepted-and-useful
The University of Michigan polled older adult responders – and the results are in. In a recent survey of more than 1000 adults aged 50+, the University of Michigan poll, fielded inside Michigan and nationwide, demonstrates that Artificial Intelligence technology is useful to older adults – and that they are not intimidated by it. As with other studies, those with less education had somewhat less trust in AI-enabled information, and those with health disabilities also were somewhat less trusting of the information they found. (Source: July, 2025 University of Mic…
Source https://www.ageinplacetech.com/blog/ai-and-older-adults-surprise-surprise-it-accepted-and-useful
The University of Michigan polled older adult responders – and the results are in. In a recent survey of more than 1000 adults aged 50+, the University of Michigan poll, fielded inside Michigan and nationwide, demonstrates that Artificial Intelligence technology is useful to older adults – and that they are not intimidated by it. As with other studies, those with less education had somewhat less trust in AI-enabled information, and those with health disabilities also were somewhat less trusting of the information they found. (Source: July, 2025 University of Mic…
Source https://www.fightaging.org/archives/2025/08/immune-aging-as-a-contribution-to-type-2-diabetes-risk/
People who do not put on a lot of excess weight, and the excess visceral fat tissue that goes with it, are very unlikely to develop type 2 diabetes. It is a metabolic disease in which the primary, addressable cause is the presence of too much visceral fat. Adoption of a low calorie diet and undergoing the consequent weight loss is a curative strategy, and can reverse the course of type 2 diabetes even in late stages of the condition. With all that said, typically, overweight people develop type 2 diabetes later in life. It takes a great deal of visceral fat tissue to push someone into type 2 diabetes in earlier adulthood. So clearly the <a hre…
Source https://www.fightaging.org/archives/2025/08/immune-aging-as-a-contribution-to-type-2-diabetes-risk/
People who do not put on a lot of excess weight, and the excess visceral fat tissue that goes with it, are very unlikely to develop type 2 diabetes. It is a metabolic disease in which the primary, addressable cause is the presence of too much visceral fat. Adoption of a low calorie diet and undergoing the consequent weight loss is a curative strategy, and can reverse the course of type 2 diabetes even in late stages of the condition. With all that said, typically, overweight people develop type 2 diabetes later in life. It takes a great deal of visceral fat tissue to push someone into type 2 diabetes in earlier adulthood. So clearly the <a hre…