Short In Vivo Reprogramming Treatment Reverses Age-Related Omics Changes in Mice

Source https://www.fightaging.org/archives/2022/01/short-in-vivo-reprogramming-treatment-reverses-age-related-omics-changes-in-mice/

Researchers here demonstrate that, in mice, many biological markers of aging (in the epigenome, transcriptome, and metabolome) are made more youthful by a short in vivo exposure to the Yamanaka factors capable of reprogramming cells into induced pluripotent stem cells. That process also resets epigenetic marks on the genome to a youthful configuration, improving mitochondrial function, among other benefits. In this case, the …

Source https://www.fightaging.org/archives/2022/01/short-in-vivo-reprogramming-treatment-reverses-age-related-omics-changes-in-mice/

Researchers here demonstrate that, in mice, many biological markers of aging (in the epigenome, transcriptome, and metabolome) are made more youthful by a short in vivo exposure to the Yamanaka factors capable of reprogramming cells into induced pluripotent stem cells. That process also resets epigenetic marks on the genome to a youthful configuration, improving mitochondrial function, among other benefits. In this case, the …

Hypnagogic Jerks: Why You’re Twilight Twitching as You Fall Asleep

Source https://greatist.com/health/hypnagogic-jerk

A hypnagogic jerk (aka hypnic jerk or sleep starts) is a sudden, brief, and strong contraction of the body — or a segment of your body — that happens as you’re falling asleep.

Sleep starts usually involve one strong jerk that moves most of your body, with the arms and legs more likely to be affected. This can jolt you awake before you have the chance to fall asleep. In most cases, the movement won’t prevent you from falling asleep (…but your partner might not be so lucky).

So should you be concerned about this unwanted nighttime activity?

What causes hypnagogic jerks? 

We don’t really know exactly what causes hypnagogic jerks, but experts have some ideas.

These involuntary movements that happen as you’re falling asleep may be linked to: 

    <…

Source https://greatist.com/health/hypnagogic-jerk

A hypnagogic jerk (aka hypnic jerk or sleep starts) is a sudden, brief, and strong contraction of the body — or a segment of your body — that happens as you’re falling asleep.

Sleep starts usually involve one strong jerk that moves most of your body, with the arms and legs more likely to be affected. This can jolt you awake before you have the chance to fall asleep. In most cases, the movement won’t prevent you from falling asleep (…but your partner might not be so lucky).

So should you be concerned about this unwanted nighttime activity?

What causes hypnagogic jerks? 

We don’t really know exactly what causes hypnagogic jerks, but experts have some ideas.

These involuntary movements that happen as you’re falling asleep may be linked to: 

    <…

The Messiness of Being Human and Why We Shouldn’t Judge Each Other

Source https://tinybuddha.com/blog/the-messiness-of-being-human-and-why-we-shouldnt-judge-each-other/

“Those who understand will never judge, and those who judge will never understand.” ~Wilson Kanadi

I’m waiting for my mother’s nurse to pick up. The hospital recording has been on a loop for twenty minutes: “Our hospital is committed to integrity, to the destitute, the sick. Our physicians and nurses have trained at some of the most prestigious colleges in the country. Our patients’ health and comfort is our #1 priority.”

The woman on the recording sounds so clear and passionate. I can picture her in the recording studio. Maybe she had to audition for the part. Maybe she got paid a lot of money to say these things. Finally, a nurse picks up. She sounds exhausted. Would never have gotten the part.

“Has anyone been in to see my mother? She’s hysterical and …

Source https://tinybuddha.com/blog/the-messiness-of-being-human-and-why-we-shouldnt-judge-each-other/

“Those who understand will never judge, and those who judge will never understand.” ~Wilson Kanadi

I’m waiting for my mother’s nurse to pick up. The hospital recording has been on a loop for twenty minutes: “Our hospital is committed to integrity, to the destitute, the sick. Our physicians and nurses have trained at some of the most prestigious colleges in the country. Our patients’ health and comfort is our #1 priority.”

The woman on the recording sounds so clear and passionate. I can picture her in the recording studio. Maybe she had to audition for the part. Maybe she got paid a lot of money to say these things. Finally, a nurse picks up. She sounds exhausted. Would never have gotten the part.

“Has anyone been in to see my mother? She’s hysterical and …

Rest Assured: The 9 Best Queen Mattresses of 2022

Source https://greatist.com/live/best-queen-mattress

Did you know that you spend approximately one-third of your life sleeping? And that doesn’t include the time you spend doing anything else in bed, like counting sheep, Netflix-ing or sexy time.

Basically, you spend a lot of time in bed. And you deserve to be comfy. And whether you’re sharing a bed with your partner, or just wanna splay out on your bed and live your best life, a queen mattress is the perfect size — big, but not so big that it takes over your entire room (lookin’ at y’all, California Kings).

Our list of the best queen mattresses can help you find the right fit for you.

Best queen mattresses

Source https://greatist.com/live/best-queen-mattress

Did you know that you spend approximately one-third of your life sleeping? And that doesn’t include the time you spend doing anything else in bed, like counting sheep, Netflix-ing or sexy time.

Basically, you spend a lot of time in bed. And you deserve to be comfy. And whether you’re sharing a bed with your partner, or just wanna splay out on your bed and live your best life, a queen mattress is the perfect size — big, but not so big that it takes over your entire room (lookin’ at y’all, California Kings).

Our list of the best queen mattresses can help you find the right fit for you.

Best queen mattresses

The Relationship Between Immunosenescence and Inflammaging

Source https://www.fightaging.org/archives/2022/01/the-relationship-between-immunosenescence-and-inflammaging/

Immunosenescence is the age-related incapacity of the immune system, while inflammaging is the age-related overactivity of the immune system, overreacting to signals of damage in the body. Both are disruptive to tissue function, health, and odds of survival in later life. They are flip sides of the same coin, labels for emergent properties of the combined interactions of many forms of damage and dysfunction that accumulate with age. The decline of the immune system is clearly important in the onset and progression of many age-related conditions; more resources should be devoted to approaches capable of immune rejuvenation, such as <a href="htt…

Source https://www.fightaging.org/archives/2022/01/the-relationship-between-immunosenescence-and-inflammaging/

Immunosenescence is the age-related incapacity of the immune system, while inflammaging is the age-related overactivity of the immune system, overreacting to signals of damage in the body. Both are disruptive to tissue function, health, and odds of survival in later life. They are flip sides of the same coin, labels for emergent properties of the combined interactions of many forms of damage and dysfunction that accumulate with age. The decline of the immune system is clearly important in the onset and progression of many age-related conditions; more resources should be devoted to approaches capable of immune rejuvenation, such as <a href="htt…

All It Takes Is One Person to Start a Chain Reaction of Caring and Kindness

Source https://tinybuddha.com/blog/all-it-takes-is-one-person-to-start-a-chain-reaction-of-caring-and-kindness/

“People will never know how far a little kindness can go. You just may start a chain reaction.” ~Rachel Joy Scott

One afternoon a while back, after stepping onboard to a full train car with no available seats, I situated myself in the standing section.

A couple of stops later, two passengers vacated their seats, allowing me the chance to sit. I embraced the opportunity to people-watch. The woman in front of me began chapter four of her book, titled How to Jump for Your Life. The girl next to her alternated between the Tinder app and a school report. A little dog ruffed from the black duffel bag on the lap of the woman across the aisle from me.

One minute I was staring down at my iPhone screen—earphones in, listening to…

Source https://tinybuddha.com/blog/all-it-takes-is-one-person-to-start-a-chain-reaction-of-caring-and-kindness/

“People will never know how far a little kindness can go. You just may start a chain reaction.” ~Rachel Joy Scott

One afternoon a while back, after stepping onboard to a full train car with no available seats, I situated myself in the standing section.

A couple of stops later, two passengers vacated their seats, allowing me the chance to sit. I embraced the opportunity to people-watch. The woman in front of me began chapter four of her book, titled How to Jump for Your Life. The girl next to her alternated between the Tinder app and a school report. A little dog ruffed from the black duffel bag on the lap of the woman across the aisle from me.

One minute I was staring down at my iPhone screen—earphones in, listening to…

Senior Planet Book Club: Arsenic and Adobo (Week 1)

Source https://seniorplanet.org/senior-planet-book-club-arsenic-and-adobo-week-1/

The votes are in!

The post Senior Planet Book Club: <em>Arsenic and Adobo</em> (Week 1) appeared first on Senior Planet.

Source https://seniorplanet.org/senior-planet-book-club-arsenic-and-adobo-week-1/

The votes are in!

The post Senior Planet Book Club: <em>Arsenic and Adobo</em> (Week 1) appeared first on Senior Planet.

A Popular Science Overview of the State of Development for Epigenetic Clocks

Source https://www.fightaging.org/archives/2022/01/a-popular-science-overview-of-the-state-of-development-for-epigenetic-clocks/

The development of rejuvenation therapies is haphazard and inefficient in part because measuring rejuvenation is costly, uncertain, and slow. On the one hand, rigorous and convincing data is needed to persuade conservative, risk-averse regulators and sources of funding to support work on rejuvenation at all. Further, cost-effective early guidance on whether one approach is better or worse than another is needed in to order to avoid a great deal of effort directed towards programs that cannot produce sizable outcomes for health.

With this in mind, the research community is in search of a way to rapidly assess biological age before and after potential therapies. Epigenetic clocks are one possible path towards this capability, but as today’s popular science article notes, there are siz…

Source https://www.fightaging.org/archives/2022/01/a-popular-science-overview-of-the-state-of-development-for-epigenetic-clocks/

The development of rejuvenation therapies is haphazard and inefficient in part because measuring rejuvenation is costly, uncertain, and slow. On the one hand, rigorous and convincing data is needed to persuade conservative, risk-averse regulators and sources of funding to support work on rejuvenation at all. Further, cost-effective early guidance on whether one approach is better or worse than another is needed in to order to avoid a great deal of effort directed towards programs that cannot produce sizable outcomes for health.

With this in mind, the research community is in search of a way to rapidly assess biological age before and after potential therapies. Epigenetic clocks are one possible path towards this capability, but as today’s popular science article notes, there are siz…

People We Love: Richard Turner, Card Shark Turned Tech Entrepreneur

Source https://seniorplanet.org/peoplewe-love-richard-turner-card-shark-tech-entrepreneur/

Richard Turner is a world-famous sleight-of-hand performer, a black belt in karate, and a motivational speaker–with one more trick up his sleeve.

The post People We Love: Richard Turner, Card Shark Turned Tech Entrepreneur appeared first on Senior Planet.

Source https://seniorplanet.org/peoplewe-love-richard-turner-card-shark-tech-entrepreneur/

Richard Turner is a world-famous sleight-of-hand performer, a black belt in karate, and a motivational speaker–with one more trick up his sleeve.

The post People We Love: Richard Turner, Card Shark Turned Tech Entrepreneur appeared first on Senior Planet.

Working with Your Inner Resistance

Source https://zenhabits.net/resistless/

By Leo Babauta

When we’re feeling some inner resistance to a task, we tend to put it off — check email, social media, our favorite distractions or busywork. We all do it.

We often turn it into something bad: I suck for not being disciplined, I suck for not being able to focus, I’m not strong enough, etc etc. But it’s just a part of being human — we all have fear, uncertainty, doubt, resistance built into our survival instincts.

The trick is not to judge the resistance, but to work with it.

Let’s talk about how to work with resistance. But first, let me make some distinctions clear.

Important Distinctions When Working with Resistance

There are some things we need to make clear before we start:

  • Sometimes we have resistance to things that are harmful to us — bein…

Source https://zenhabits.net/resistless/

By Leo Babauta

When we’re feeling some inner resistance to a task, we tend to put it off — check email, social media, our favorite distractions or busywork. We all do it.

We often turn it into something bad: I suck for not being disciplined, I suck for not being able to focus, I’m not strong enough, etc etc. But it’s just a part of being human — we all have fear, uncertainty, doubt, resistance built into our survival instincts.

The trick is not to judge the resistance, but to work with it.

Let’s talk about how to work with resistance. But first, let me make some distinctions clear.

Important Distinctions When Working with Resistance

There are some things we need to make clear before we start:

  • Sometimes we have resistance to things that are harmful to us — bein…

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