Author: Tom

Source https://www.fightaging.org/archives/2025/08/reviewing-the-aging-of-the-intestines/

Humans tend to die from cardiovascular aging, while flies tend to die from intestinal aging. The intestines of humans age and become dysfunctional, as they do in flies, of course. But intestinal aging usually isn’t a severe enough cause of issues in and of itself to win out over cardiovascular disease, pulmonary disease, and the other more common causes of death. It may well contribute meaningfully to all of those other causes of mortality! The converse can be said for the aging of the cardiovascular system in f…

Source https://www.fightaging.org/archives/2025/08/an-example-of-the-harms-done-by-too-little-circulating-klotho/

When people talk about klotho, they usually mean α-klotho, and specifically the soluble fragment of α-klotho that is secreted by cells to circulate in the body. Researchers have demonstrated in animal studies that high levels of α-klotho slow aging to extend life while low levels accelerate aging to shorten life. In humans, higher circulating levels of α-klotho correlate with a lower risk of age-related disease and longer life expectancy, and vice versa. Enumerating the mechanisms by which α-klotho affects the pace of aging, and determining which are more or less important than the others, remains a work in progress. The research noted here is an example of this ongoing work, and is focused on the effects that α-klotho ha…

Source https://www.fightaging.org/archives/2025/08/too-much-klotho-increases-cancer-risk-in-cancer-survivors/

An infrequently discussed topic in aging circles is the point that we should probably expect any therapy that improves tissue maintenance and regeneration in old people to also increase cancer risk. There isn’t much in the way of evidence to support that position, but it seems worthy of consideration. Cancer is a numbers game, and the greater the activity undertaken by stem cells and progenitor cells, the greater the likelihood of cancerous mutations. The only exceptions are interventions that act to improve the function of the immune system in addition to any other benefits that they produce; such treatments could lead to a net reduction in cancer risk, due to improved immunosurveillance of potent…

Source https://www.fightaging.org/archives/2025/07/accelerated-biological-age-measures-correlate-with-a-higher-risk-of-disease-and-mortality/

Biological age acceleration is the name given to the state of exhibiting a predicted age from an aging clock that is higher than chronological age. Accelerated age via a clock measure is correlated with an increased risk of age-related disease and mortality. This has been demonstrated in a number of large epidemiological studies, and here researchers make use of the UK Biobank data to once again demonstrate that aging clocks do at least somewhat reflect the age-related risk of disease and mortality. Even so, it remains possible to argue over what exactly the clocks are measuring; calling it biological age is a lazy shortcut and possibly not the reality.
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Source https://tinybuddha.com/blog/left-side-pain-a-powerful-messenger-for-my-abandoned-parts/

“The body always leads us home… if we’re willing to listen.”

For over a decade, I lived in a body that tried to tell me something I wasn’t ready to hear. But eventually, it got louder—loud enough that I could no longer ignore the message.

It started with migraines—always on the left side.

Then came a string of sinus infections and dental issues—again, always on the left.

Lumps formed in my left breast. Then pain in my left ribs. Then a left-sided numbness that made doctors run MRIs for multiple sclerosis. Every test came back normal. And yet my body felt anything but.

At one point, I even developed pa…

Source https://www.fightaging.org/archives/2025/07/further-assessment-of-an-organ-specific-proteomic-aging-clock/

You might recall the development a few years ago of a proteomic aging clock that provided estimates of biological age for various organs in the body, rather than simply one overall measure. It was noted that individuals tended to have a distribution of biological ages across various organs, an individual’s organs age to different degrees. Here, researchers apply that clock to a subset of the UK Biobank population, and find that it produces the expected results. A higher predicted biological age for a given organ resulting from the clock algorithm correlates with a higher future risk of age-related disease in that organ, and the more organs exhibiting accelerated biological age, the greater the risk…

Source https://www.fightaging.org/archives/2025/07/mitrix-bio-set-to-test-mitochondrial-transplantation-in-volunteers/

Every cell contains hundreds of mitochondria, vital organelles tightly integrated into many core cellular processes, and responsible for producing adenosine triphosphate, a chemical energy store molecule used to power the cell. Unfortunately mitochondria become dysfunctional with age, and this is thought to be an important contribution to degenerative aging. A variety of means to address this issue exist or are under development, some more direct and ambitious than others.

Cells will readily take up whole mitochondria from the surrounding tissue environment and make use of them. Thus it is possible to introduce large numbers of mitochondria harvested from cell cultures into a tissue in order…

Source https://www.ageinplacetech.com/blog/caregiving-us-2025-more-tech-not-much-caregivers-could-use

Source https://tinybuddha.com/blog/how-two-simple-lists-completely-transformed-my-life/

“Happiness turned to me and said, ‘It is time. It is time to forgive yourself for all of the things you did not become… Above all else, it is time to believe, with reckless abandon, that you are worthy of me, for I have been waiting for years.” ~Bianca Sparacino

I didn’t know who I was.

That realization hit me like a punch to the chest after I ended a decade-long relationship and canceled my wedding six weeks before it was supposed to happen.

I remember standing in my kitchen one morning, staring at the floor, and thinking, I have no idea what kind of music I actually like.

That might sound small, but it was th…

Source https://www.americanspa.com/premium/webinar/205889

Barrier First: Building a Foundation for Long-Term Clarity
swheeler
Thu, 07/24/2025 – 11:32

Mon, 09/15/2025 – 13:00