It is never too late to start
Source https://www.theminimalists.com/saditems/
The Minimalists discuss so-called “sad items”—and why Ikea is hell on earth.
What purchases make you sad? Let us know in the YouTube comments.
The post These Purchases Will Make You Sad appeared first on The Minimalists.
…
Source https://www.theminimalists.com/saditems/
The Minimalists discuss so-called “sad items”—and why Ikea is hell on earth.
What purchases make you sad? Let us know in the YouTube comments.
The post These Purchases Will Make You Sad appeared first on The Minimalists.
…
Source https://www.fightaging.org/archives/2025/10/chga-variants-correlate-with-longevity/
The search for genetic determinants of longevity in humans has, on the whole, not gone well. Only a very small number of widespread gene variants (such as those in the APOE gene) manage to show effects on life span in multiple study populations, and their effect sizes are largely much smaller than those attributed to exercise. The modern existence of large genetic databases has, if anything, pushed down the estimate of the degree to which genetic variation contributes to longevity. The study of the genetics of extremely long-lived individuals has been underway a while and has not produced data to support a credible set of longevity genes…
Source https://www.fightaging.org/archives/2025/10/chga-variants-correlate-with-longevity/
The search for genetic determinants of longevity in humans has, on the whole, not gone well. Only a very small number of widespread gene variants (such as those in the APOE gene) manage to show effects on life span in multiple study populations, and their effect sizes are largely much smaller than those attributed to exercise. The modern existence of large genetic databases has, if anything, pushed down the estimate of the degree to which genetic variation contributes to longevity. The study of the genetics of extremely long-lived individuals has been underway a while and has not produced data to support a credible set of longevity genes…
Source https://www.theminimalists.com/p508/
The Minimalists talk about the pros and cons of extreme minimalism, when simple living goes too far, so-called “sad” items, and much more.
Have a question for the show? Call 406-219-7839 or email a voice memo to podcast@themins.com.
Source https://www.theminimalists.com/p508/
The Minimalists talk about the pros and cons of extreme minimalism, when simple living goes too far, so-called “sad” items, and much more.
Have a question for the show? Call 406-219-7839 or email a voice memo to podcast@themins.com.
Source https://www.fightaging.org/archives/2025/10/type-2-diabetes-accelerates-age-related-disease/
Type 2 diabetes is near entirely a condition caused by the presence of excess visceral fat tissue, by being overweight or obese. Even in relatively late stages, type 2 diabetes can be reversed by low calorie diets and the consequent loss of that excess visceral fat. Visceral fat is metabolically active, and directly provokes chronic inflammation through a range of mechanisms, such as by mimicking the signaling of cells infected by pathogens. Excess visce…
Source https://www.fightaging.org/archives/2025/10/type-2-diabetes-accelerates-age-related-disease/
Type 2 diabetes is near entirely a condition caused by the presence of excess visceral fat tissue, by being overweight or obese. Even in relatively late stages, type 2 diabetes can be reversed by low calorie diets and the consequent loss of that excess visceral fat. Visceral fat is metabolically active, and directly provokes chronic inflammation through a range of mechanisms, such as by mimicking the signaling of cells infected by pathogens. Excess visce…
Source https://seniorplanet.org/articles-dad-help-terrifying-scam/
Inside a virtual kidnapping: a 65-year-old retiree answered a call from an unknown number—and heard a scream, “Dad, I need your help!”
The post <em>“Dad, HELP!!!”</em> – Terrifying New Scam Targets Elders appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-dad-help-terrifying-scam/
Inside a virtual kidnapping: a 65-year-old retiree answered a call from an unknown number—and heard a scream, “Dad, I need your help!”
The post <em>“Dad, HELP!!!”</em> – Terrifying New Scam Targets Elders appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-open-thread-favorite-one-hit-wonder/
Virge celebrates the musicians who actually grasped the brass ring…and then lost it. Let’s hear it for the one hit wonders – what are your faves?
The post Open Thread: Favorite One Hit Wonders appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-open-thread-favorite-one-hit-wonder/
Virge celebrates the musicians who actually grasped the brass ring…and then lost it. Let’s hear it for the one hit wonders – what are your faves?
The post Open Thread: Favorite One Hit Wonders appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2025/10/fight-aging-newsletter-october-6th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
Source https://www.fightaging.org/archives/2025/10/fight-aging-newsletter-october-6th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
Source https://www.sonima.com/yoga/yoga-articles/active-test/
This content is password protected. To view it please enter your password below:
The post Protected: New Active Series Teacher Training Sessions Set appeared first on Sonima.
…
Source https://www.sonima.com/yoga/yoga-articles/active-test/
This content is password protected. To view it please enter your password below:
The post Protected: New Active Series Teacher Training Sessions Set appeared first on Sonima.
…
Source https://www.fightaging.org/archives/2025/09/pai-1-expression-is-involved-in-muscle-aging/
PAI-1 expression increases with age, and is implicated in cellular senescence, inflammation, and detrimental remodeling of tissue, such as the generation of fibrosis. These line items are all connected, as a burden of lingering senescent cells tissues has been shown to be sufficient to cause the other two, but nothing is biochemistry is ever as simple as it first appears.
PAI-1 in the context of aging has received increased research interest since the discovery of a small population of human loss-of-function mutants who live…
Source https://www.fightaging.org/archives/2025/09/pai-1-expression-is-involved-in-muscle-aging/
PAI-1 expression increases with age, and is implicated in cellular senescence, inflammation, and detrimental remodeling of tissue, such as the generation of fibrosis. These line items are all connected, as a burden of lingering senescent cells tissues has been shown to be sufficient to cause the other two, but nothing is biochemistry is ever as simple as it first appears.
PAI-1 in the context of aging has received increased research interest since the discovery of a small population of human loss-of-function mutants who live…
Older epidemiological study data sometimes offers the potential for reanalysis with modern aging clock algorithms to assess biological age. If the study continued since the data was obtained, then there is the possibility to demonstrate that measures of biological age do correlate well with specific long-term outcomes. The downside is that researchers are limited by past choices regarding what was measured, and thus which clocks can be used, and often limited in the degree to which data obtained decades ago remains accessible. Nonetheless, sometimes it works out and we see results such as those reported here. A study has followed one birth cohort since the late 1940s, and proteomic data was obtained 15 years ago. That data has now been used to assess biolo…
Older epidemiological study data sometimes offers the potential for reanalysis with modern aging clock algorithms to assess biological age. If the study continued since the data was obtained, then there is the possibility to demonstrate that measures of biological age do correlate well with specific long-term outcomes. The downside is that researchers are limited by past choices regarding what was measured, and thus which clocks can be used, and often limited in the degree to which data obtained decades ago remains accessible. Nonetheless, sometimes it works out and we see results such as those reported here. A study has followed one birth cohort since the late 1940s, and proteomic data was obtained 15 years ago. That data has now been used to assess biolo…