Author: Tom

Source https://www.fightaging.org/archives/2025/09/pai-1-expression-is-involved-in-muscle-aging/

PAI-1 expression increases with age, and is implicated in cellular senescence, inflammation, and detrimental remodeling of tissue, such as the generation of fibrosis. These line items are all connected, as a burden of lingering senescent cells tissues has been shown to be sufficient to cause the other two, but nothing is biochemistry is ever as simple as it first appears.

PAI-1 in the context of aging has received increased research interest since the discovery of a small population of human loss-of-function mutants who live…

Source https://www.fightaging.org/archives/2025/10/applying-a-proteomic-aging-clock-to-data-from-a-very-long-running-epidemiological-study/

Older epidemiological study data sometimes offers the potential for reanalysis with modern aging clock algorithms to assess biological age. If the study continued since the data was obtained, then there is the possibility to demonstrate that measures of biological age do correlate well with specific long-term outcomes. The downside is that researchers are limited by past choices regarding what was measured, and thus which clocks can be used, and often limited in the degree to which data obtained decades ago remains accessible. Nonetheless, sometimes it works out and we see results such as those reported here. A study has followed one birth cohort since the late 1940s, and proteomic data was obtained 15 years ago. That data has now been used to assess biolo…

Source https://www.fightaging.org/archives/2025/10/senescent-oligodendrocyte-precursor-cells-contribute-to-the-aging-of-the-brain/

Considerations of the role of dysfunction of oligodendrocytes and their precursor cell population in aging usually focus on myelination. Oligodendrocytes are responsible for maintaining the insulating myelin structure that wraps the axons that connect neurons, and which is required for effective propagation of nerve impulses. Researchers have shown that this function declines with age, perhaps to a meaningful degree. Here, however, researchers instead focus on the effects of cellular senescence in oligodendrocyte precursor …

Source https://www.fightaging.org/archives/2025/10/continued-progress-towards-reversible-vitrification-of-organs/

Cryonics is important. Low-temperature storage of the brain is presently the only near-term approach that can provide those who die from old age with some greater than zero chance at a renewed life in the future. The cryonics industry has remained small since its inception decades ago, and only a few hundred people have been cryopreserved. The best way to expand and advance the small cryonics industry is to develop reversible vitrification of organs, a capability that has been demonstrated at the small scale in laboratories, and which ha…

Source https://www.fightaging.org/archives/2025/10/mt1-mmp-inhibition-restores-some-lost-cognitive-function-in-both-aged-mice-and-obese-mice/

There is at present a tremendous appetite for the development of novel pharmacological approaches to weight loss. This is in large part a response to the rising prevalence of obesity. No robustly proven answer exists as to the question of why exactly people are now becoming obese in such large numbers. There is no shortage of hypotheses, from excessive use of modern sugar substitutes to lack of exercise to specific widespread dietary additives to the presence of microplastics in the environment to changes in the average gut microbiome composition. The absence of a good answer and means of prevention means that efforts have turned to pharmacology for weight loss. This is not a new phenomenon, weight loss drugs have been greeted with enthusiasm since use of the …

Source https://www.nerdfitness.com/blog/brew-a-balanced-plate/

Halloween is just around the corner, and while I won’t be handing out any spell books, I will share a little witchcraft for building meals that actually work in real life.

One of my clients was struggling recently. Between long workdays and late nights caring for her sick pup, she didn’t have the time or brainpower to cook elaborate meals. She wanted something simple:

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Source https://www.nerdfitness.com/blog/5-minute-mobility/

I got a great follow-up question to my recent newsletter about “​What does enough fitness look like?​” And I thought it may help you, too.