Source https://www.fightaging.org/archives/2021/10/age-versus-frailty-as-a-predictor-of-mortality/
A number of companies and research groups are performing drug discovery by using effects on frailty in mice as a readout. To what degree is frailty an adequate measure of the harms done by aging? One way to answer that question is to assess mortality in a human study population against a measure of frailty, with and without factoring in chronological age. Researchers here show that frailty is a fair marker for age-related mortality, but it is not a reflection of every degenerative, harmful process taking place under the hood. Frailty and age combined provide a better correlation with mortality than frailty alone, indicating that there are aspects of age-related decline that contribute meaningfully to mortality without producing evident frailty.
As populations get older, the association between chronological age and health status becomes increasingly heterogeneous. To describe this heterogen…
Source https://www.fightaging.org/archives/2021/10/age-versus-frailty-as-a-predictor-of-mortality/
A number of companies and research groups are performing drug discovery by using effects on frailty in mice as a readout. To what degree is frailty an adequate measure of the harms done by aging? One way to answer that question is to assess mortality in a human study population against a measure of frailty, with and without factoring in chronological age. Researchers here show that frailty is a fair marker for age-related mortality, but it is not a reflection of every degenerative, harmful process taking place under the hood. Frailty and age combined provide a better correlation with mortality than frailty alone, indicating that there are aspects of age-related decline that contribute meaningfully to mortality without producing evident frailty.
As populations get older, the association between chronological age and health status becomes increasingly heterogeneous. To describe this heterogen…
Source https://minimalistbaker.com/vegan-chorizo-sausage-links/
After perfecting Vegan Sausage Links and Easy Vegan Chorizo, we knew what we had to do: Vegan Chorizo Links! By tweaking and combining the two recipes, we’ve created the best of both worlds — smoky, spicy flavor, but in link form!
Even better? They’re plant-based, gluten-free, soy-free, and made with just 10 wholesome ingredients! Not only are these chorizo links packed with flavor and super satisfying, but they’re incredibly versatile and so great as …
Source https://minimalistbaker.com/vegan-chorizo-sausage-links/
After perfecting Vegan Sausage Links and Easy Vegan Chorizo, we knew what we had to do: Vegan Chorizo Links! By tweaking and combining the two recipes, we’ve created the best of both worlds — smoky, spicy flavor, but in link form!
Even better? They’re plant-based, gluten-free, soy-free, and made with just 10 wholesome ingredients! Not only are these chorizo links packed with flavor and super satisfying, but they’re incredibly versatile and so great as …
Source https://www.fightaging.org/archives/2021/10/clarifying-the-hyperfunction-theory-of-aging/
My encounters with the hyperfunction theory of aging have at times left me confused, and I suspect that not all of those arguing for it are working from exactly the same picture in their heads. The version presented in today’s editorial is somewhat more clear, possibly because the primary intent of the paper is to clarify. It is worth noting up front that the author is very much a proponent of the centrality of mTOR and related signaling pathways in aging, in the sense that aging and age-related degeneration is a program of regulatory change that produces damage. The opposing mainstream viewpoint in the research community is that <a href="https://www.fightagi…
Source https://www.fightaging.org/archives/2021/10/clarifying-the-hyperfunction-theory-of-aging/
My encounters with the hyperfunction theory of aging have at times left me confused, and I suspect that not all of those arguing for it are working from exactly the same picture in their heads. The version presented in today’s editorial is somewhat more clear, possibly because the primary intent of the paper is to clarify. It is worth noting up front that the author is very much a proponent of the centrality of mTOR and related signaling pathways in aging, in the sense that aging and age-related degeneration is a program of regulatory change that produces damage. The opposing mainstream viewpoint in the research community is that <a href="https://www.fightagi…
Source http://feedproxy.google.com/~r/tinybuddha/~3/nzKKtVQtfos/
“Your mind, emotions, and body are instruments and the way you align and tune them determines how well you play life.” ~Harbhajan Singh Yogi
The earliest memory of my anxiety was at ten years old in fifth grade.
I remember it so vividly because in middle school the bus came at 6:22am exactly in the morning.
Each night I would look at my Garfield clock and think, “If I fall asleep now, I’ll get five hours of sleep…. If I fall asleep now, I’ll get four hours of sleep… If I fall asleep now, I’ll get three hours of sleep…”
And without fail, my sister would slam my door open at 6:15 because my alarm didn’t wake me, yelling that we’re going to miss the bus, and this is the last time she’s going to wake me up.
I didn’t know I ha…
Source http://feedproxy.google.com/~r/tinybuddha/~3/nzKKtVQtfos/
“Your mind, emotions, and body are instruments and the way you align and tune them determines how well you play life.” ~Harbhajan Singh Yogi
The earliest memory of my anxiety was at ten years old in fifth grade.
I remember it so vividly because in middle school the bus came at 6:22am exactly in the morning.
Each night I would look at my Garfield clock and think, “If I fall asleep now, I’ll get five hours of sleep…. If I fall asleep now, I’ll get four hours of sleep… If I fall asleep now, I’ll get three hours of sleep…”
And without fail, my sister would slam my door open at 6:15 because my alarm didn’t wake me, yelling that we’re going to miss the bus, and this is the last time she’s going to wake me up.
I didn’t know I ha…
Source https://greatist.com/discover/hispanic-heritage-month-playlist
Happy Hispanic Heritage Month! This month of celebration, culture, and sound is prime time for learning and participation. And what better way to participate than with movement?
Let this heat-infused mix move you through the remainder of this month, as you dance till you break a sweat, swoon until you float away, or just lie still and let your heart beat to the rhythms.
Follow us on Spotify and bookmark this playlist to be swept up in good feels whenever the mood strikes.
And shout-out to our special guest DJ, Yvonne Armenta, for curating these 2 hours and 33 minutes of Latinx/a/o music hotness! Give her affirmations podcast, “…
Source https://greatist.com/discover/hispanic-heritage-month-playlist
Happy Hispanic Heritage Month! This month of celebration, culture, and sound is prime time for learning and participation. And what better way to participate than with movement?
Let this heat-infused mix move you through the remainder of this month, as you dance till you break a sweat, swoon until you float away, or just lie still and let your heart beat to the rhythms.
Follow us on Spotify and bookmark this playlist to be swept up in good feels whenever the mood strikes.
And shout-out to our special guest DJ, Yvonne Armenta, for curating these 2 hours and 33 minutes of Latinx/a/o music hotness! Give her affirmations podcast, “…
Source https://minimalistbaker.com/vegan-chorizo-breakfast-tacos/
After creating our flavor-packed Easy Vegan Chorizo (and Chorizo Links), we knew we had to create something that made them the star of the show! Say hello to your new favorite breakfast: Chorizo Breakfast Tacos! Tender roasted potatoes, flavorful plant-based chorizo, sweet and spicy salsa, and creamy avocado combine for an explosion of flavors and textures wrapped in warm corn tortillas.
Fuel your day with these filling, versatile, protein-packed tacos.
<a href="https://m…
Source https://minimalistbaker.com/vegan-chorizo-breakfast-tacos/
After creating our flavor-packed Easy Vegan Chorizo (and Chorizo Links), we knew we had to create something that made them the star of the show! Say hello to your new favorite breakfast: Chorizo Breakfast Tacos! Tender roasted potatoes, flavorful plant-based chorizo, sweet and spicy salsa, and creamy avocado combine for an explosion of flavors and textures wrapped in warm corn tortillas.
Fuel your day with these filling, versatile, protein-packed tacos.
<a href="https://m…
Source https://www.fightaging.org/archives/2021/10/how-much-of-the-benefit-of-a-healthier-diet-is-due-to-natural-calorie-restriction-mimetics/
How much of the benefit of a healthier diet arises from the effects of natural calorie restriction mimetic compounds? That question is an interesting one from a scientific perspective, but the answers are probably not all that valuable in a practical sense. We have a fairly good idea as to the size of the benefits to long-term health obtained via a better diet, and separately by eating less of that diet, the practice of calorie restriction while still obtaining sufficient micronutrients. Calorie restriction mimetic compounds trigger some of the same beneficial cellular stress response mechanisms as does a low calorie diet, though in lesser and more piecemeal ways. Knowing more about how and why a better diet is a better diet isn’t the path to large improvements in h…
Source https://www.fightaging.org/archives/2021/10/how-much-of-the-benefit-of-a-healthier-diet-is-due-to-natural-calorie-restriction-mimetics/
How much of the benefit of a healthier diet arises from the effects of natural calorie restriction mimetic compounds? That question is an interesting one from a scientific perspective, but the answers are probably not all that valuable in a practical sense. We have a fairly good idea as to the size of the benefits to long-term health obtained via a better diet, and separately by eating less of that diet, the practice of calorie restriction while still obtaining sufficient micronutrients. Calorie restriction mimetic compounds trigger some of the same beneficial cellular stress response mechanisms as does a low calorie diet, though in lesser and more piecemeal ways. Knowing more about how and why a better diet is a better diet isn’t the path to large improvements in h…
Source https://www.theminimalists.com/p308/
By Joshua Fields Millburn & Ryan Nicodemus · Follow: Facebook, Twitter, Instagram
In this episode of The Minimalists Podcast, Joshua and Ryan talk about trading in our materialistic clinging for transcendent freedom with author, podcaster, and co…
Source https://www.theminimalists.com/p308/
By Joshua Fields Millburn & Ryan Nicodemus · Follow: Facebook, Twitter, Instagram
In this episode of The Minimalists Podcast, Joshua and Ryan talk about trading in our materialistic clinging for transcendent freedom with author, podcaster, and co…
