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Source https://www.fightaging.org/archives/2021/06/fight-aging-newsletter-june-21st-2021/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
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Contents

• A Consensus Definition of Aging Would be Useful Now, But is Unlikely to Arrive Soon Enough to Help

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Source https://www.theminimalists.com/virtual/

By Joshua Fields Millburn & Ryan Nicodemus · Follow: Facebook, Twitter, Instagram

The Minimalists are coming to a living room near you! Because certain restrictions will prevent us from hitting the road when our new book is published next month, we’ve decided to embark on a one-night worldwide virtual tour…

Source https://www.fightaging.org/archives/2021/06/leakage-of-mitochondrial-dna-into-the-cytosol-implicated-in-parkinsons-disease/

Researchers here suggest that the combined effects of mitochondrial dysfunction and lysosomal dysfunction in long-lived cells in old brains lead to a leakage of mitochondrial DNA into the body of the cell, where it provokes maladaptive inflammatory reactions that continue to the onset and progression of neurodegenerative conditions such as Parkinson’s disease. The data is interesting, but needs confirmation in more relevant models than those used to date. The challenge with research into the mechanisms of neurodegeneration is that the <a href="https://en.wikipedia.org…

Source https://www.clubindustry.com/sponsored/10-steps-to-implementing-ai-your-gym

10 Steps to Implementing AI in Your Gym
pkufahl
Wed, 06/16/2021 – 22:57
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Source http://feedproxy.google.com/~r/tinybuddha/~3/vqfWVY9BKYM/

“Never feel sorry for choosing yourself.” ~Unknown

I was eleven years old, possibly twelve, the day I first discovered my mother’s betrayal. I assume she didn’t hear me when I walked in the door after school. The distant voices in the finished basement room of our home drew me in. My mother’s voice was soft as she spoke to her friend. What was she hiding that she didn’t want me to hear?

I leaned in a little bit closer to the opening of the stairs… She was talking about a man she’d met. Her voice changed when she spoke of him. The tone of dreamy wonder when you discover something that makes your heart race. She talked about the way they touched and how she felt being with him.

I felt my body go weak. I could not tell if it was sorrow…

Source https://www.fightaging.org/archives/2021/06/a-discussion-of-mesenchymal-stem-cell-therapy-as-a-way-to-suppress-age-related-inflammation/

First generation mesenchymal stem cell therapies have been shown over the years to fairly reliably suppress chronic inflammation for some time, whether disease-associated or aging-associated. The transplanted cells die quickly, but the effects of their brief burst of signaling can last for months. Other intended benefits, such as increased regeneration or function, are in comparison unreliable at best. In part the challenge is that there is no standard in this part of the field, every clinic uses different methodologies and cell sources. These differences appear to matter greatly, and the fine details of why they matter greatly remain poorly cataloged and poorly understood.

Mese…