Senescent cells accumulate with age throughout the body, and disrupt tissue structure and function via their inflammatory sections. Work on senolytic drugs capable of clearing senescent cells from aged tissues has in recent years pointed to cellular senescence in the supporting glial cells of the brain as an important mechanism in neurodegenerative conditions. Clearing a sizable fraction of senescent microglia and astrocytes in mouse models of tauopathy reduces harmful <a h…
A Bidirectional Relationship Between Pathological Tau Aggregation and Senescent Glial Cells
Senescent cells accumulate with age throughout the body, and disrupt tissue structure and function via their inflammatory sections. Work on senolytic drugs capable of clearing senescent cells from aged tissues has in recent years pointed to cellular senescence in the supporting glial cells of the brain as an important mechanism in neurodegenerative conditions. Clearing a sizable fraction of senescent microglia and astrocytes in mouse models of tauopathy reduces harmful <a h…