Most discussion of protein aggregation is focused on the few proteins that can excessively aggregate to form solid deposits and an associated toxic biochemistry, such as amyloid-β, α-synuclein, tau, and so forth. But many proteins can aggregate to much lesser degrees, particularly when the normal processes of quality assurance and clearance are impaired. Is this broad aggregation of hundreds of specific proteins in cells in aged tissues a sufficiently important contribution to dysfunction to be worth addressing distinctly from the underlying changes in environment and epigenetic regulation of gene expression that cause this issue? That is a…
A Broad Spectrum of Protein Aggregation in Microglia in the Aging Brain
Most discussion of protein aggregation is focused on the few proteins that can excessively aggregate to form solid deposits and an associated toxic biochemistry, such as amyloid-β, α-synuclein, tau, and so forth. But many proteins can aggregate to much lesser degrees, particularly when the normal processes of quality assurance and clearance are impaired. Is this broad aggregation of hundreds of specific proteins in cells in aged tissues a sufficiently important contribution to dysfunction to be worth addressing distinctly from the underlying changes in environment and epigenetic regulation of gene expression that cause this issue? That is a…