Senescent cells grow in number in tissues throughout the body with advancing age. Cells become senescent throughout life, largely as a result of reaching the Hayflick limit on replication, but it can also happen in response to injury, or various forms of cytotoxic stress. These cells are removed by the immune system or programmed cell death and do not accumulate. Only later in life when there are greater levels of damage and cell stress on the one hand, and a failing immune system on the other hand, does creation outpace clearance…
A Cautious View of Senolytic Therapies in the Context of Cardiovascular Disease
Senescent cells grow in number in tissues throughout the body with advancing age. Cells become senescent throughout life, largely as a result of reaching the Hayflick limit on replication, but it can also happen in response to injury, or various forms of cytotoxic stress. These cells are removed by the immune system or programmed cell death and do not accumulate. Only later in life when there are greater levels of damage and cell stress on the one hand, and a failing immune system on the other hand, does creation outpace clearance…