A Discussion of Applying Partial Reprogramming to Senescent Cells In Vivo

Source https://www.fightaging.org/archives/2022/03/a-discussion-of-applying-partial-reprogramming-to-senescent-cells-in-vivo/

Partial reprogramming exposes cells to the Yamanaka factors for long enough to reset their epigenetic patterns to those of a youthful cell, but not so long as to force a change of state into induced pluripotent stem cells. This is an active area of research, not yet an exact science in practice, and the long-term risk of cancer via current techniques remains unknown, but animal studies have produced promising results in the short term when it comes to improved function following the application of a partial reprogramming therapy.

What will partial reprogramming do to senescent cells? In today’s open access paper, researchers discuss the pros…

Source https://www.fightaging.org/archives/2022/03/a-discussion-of-applying-partial-reprogramming-to-senescent-cells-in-vivo/

Partial reprogramming exposes cells to the Yamanaka factors for long enough to reset their epigenetic patterns to those of a youthful cell, but not so long as to force a change of state into induced pluripotent stem cells. This is an active area of research, not yet an exact science in practice, and the long-term risk of cancer via current techniques remains unknown, but animal studies have produced promising results in the short term when it comes to improved function following the application of a partial reprogramming therapy.

What will partial reprogramming do to senescent cells? In today’s open access paper, researchers discuss the pros…

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