In principle one could develop rejuvenation therapies without a way to measure the overall state of biological age. Each of the underlying causes of aging is measurable today: senescent cell burden, mitochondrial dysfunction, presence of amyloids, and so forth. Therapies can be assessed for efficacy in terms of the degree to which they repair the specific forms of cell and tissue damage that they are intended to repair. That doesn’t tell us how much of an effect any given therapy will have …
A High Level Overview of the Development of Aging Clocks
In principle one could develop rejuvenation therapies without a way to measure the overall state of biological age. Each of the underlying causes of aging is measurable today: senescent cell burden, mitochondrial dysfunction, presence of amyloids, and so forth. Therapies can be assessed for efficacy in terms of the degree to which they repair the specific forms of cell and tissue damage that they are intended to repair. That doesn’t tell us how much of an effect any given therapy will have …