Researchers here present an interesting approach to epigenetic clock development. Based on a large set of training data, the researchers used epigenetic data to predict clinical biomarkers, in this case circulating proteins measured in a blood sample that are relevant to the chronic inflammation of aging, an assessment of the inflammatory state of the immune system. Then the researchers used the predicted biomarkers of inflammation as a basis for predicting age. This approach to clock development has the advantage of producing results that are more explicable than a direct prediction of age from epigenetic data, as one can theorize more readily about the role of specific inflammatory markers than is the case for specific epigenetic changes. We will l…
An Aging Clock Integrating Epigenetic and Inflammatory Measures
Researchers here present an interesting approach to epigenetic clock development. Based on a large set of training data, the researchers used epigenetic data to predict clinical biomarkers, in this case circulating proteins measured in a blood sample that are relevant to the chronic inflammation of aging, an assessment of the inflammatory state of the immune system. Then the researchers used the predicted biomarkers of inflammation as a basis for predicting age. This approach to clock development has the advantage of producing results that are more explicable than a direct prediction of age from epigenetic data, as one can theorize more readily about the role of specific inflammatory markers than is the case for specific epigenetic changes. We will l…