An Approach to Reduce Mitochondrial Function in the Heart Promotes Regeneration

Source https://www.fightaging.org/archives/2024/06/an-approach-to-reduce-mitochondrial-function-in-the-heart-promotes-regeneration/

In an interesting reversal of the usual goals in aged tissue, researchers here demonstrate an approach that reduces mitochondrial function in heart muscle to provoke replication of cardiomyocyte cells and consequent regeneration. Since this is achieved via downregulation of a single gene, it is a possible basis for future therapies aimed at improving function in the aged heart, or, the more usual focus in the research community, provoking greater regeneration following the injury and scarring of a heart attack.

Newborn mammalian cardiomyocytes quickly transition from a fetal to an adult phenotype that utilizes mitochondrial oxidative phosphorylation …

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