An Epigenetic Clock For Intrinsic Capacity

Source https://www.fightaging.org/archives/2025/06/an-epigenetic-clock-for-intrinsic-capacity/

Researchers continue to produce a fair number of new aging clocks every year to attempt to measure biological age. One might at this point ask whether the life science community should instead focus on better understanding and utilizing the best of the existing clocks. No new clock can be applied naively to the assessment of potential therapies to slow or reverse aging, as a new clock arrives with no understanding of how exactly the measures making it up relate to specific forms of damage and dysfunction that drive aging. One cannot predict whether the clock will accurately reflect changes in biological age or risk of age-related disease if, for example, senescent cells are cleared, or mito…

Source https://www.fightaging.org/archives/2025/06/an-epigenetic-clock-for-intrinsic-capacity/

Researchers continue to produce a fair number of new aging clocks every year to attempt to measure biological age. One might at this point ask whether the life science community should instead focus on better understanding and utilizing the best of the existing clocks. No new clock can be applied naively to the assessment of potential therapies to slow or reverse aging, as a new clock arrives with no understanding of how exactly the measures making it up relate to specific forms of damage and dysfunction that drive aging. One cannot predict whether the clock will accurately reflect changes in biological age or risk of age-related disease if, for example, senescent cells are cleared, or mito…

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