Source https://www.fightaging.org/archives/2025/08/an-example-of-dna-repair-deficiency-accelerating-muscle-aging/
Randomly occurring mutations to nuclear DNA accumulate with age. While DNA repair machinery in the cell nucleus has evolved to be highly efficient, nonetheless some fraction of the damage accumulated via radiation and molecular interactions slips through. There is considerable debate over the degree to which the accumulation of mutations contributes to degenerative aging, and which effects are important. Clearly mutation burden increases risk of cancer, that conclusion is solid and well supported: the more mutations, the more likely it is that a cancerous combination of mutations will occur. Going beyond this, matters become less clear, however.
The current consensus on this subject is that mutations occurring in <a href="https://en.wikipedia.org/wik…
Source https://www.fightaging.org/archives/2025/08/an-example-of-dna-repair-deficiency-accelerating-muscle-aging/
Randomly occurring mutations to nuclear DNA accumulate with age. While DNA repair machinery in the cell nucleus has evolved to be highly efficient, nonetheless some fraction of the damage accumulated via radiation and molecular interactions slips through. There is considerable debate over the degree to which the accumulation of mutations contributes to degenerative aging, and which effects are important. Clearly mutation burden increases risk of cancer, that conclusion is solid and well supported: the more mutations, the more likely it is that a cancerous combination of mutations will occur. Going beyond this, matters become less clear, however.
The current consensus on this subject is that mutations occurring in <a href="https://en.wikipedia.org/wik…
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